Behavioral screen for antidepressants: the effects of drugs and electroconvulsive shock on performance under a differential-reinforcement-of-low-rate schedule.
Behavioral screen for antidepressants: the effects of drugs and electroconvulsive shock on performance under a differential-reinforcement-of-low-rate schedule.
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抗抑郁药的行为筛选：药物和电休克对低速率差异强化计划下表现的影响。
DOI：
10.1007/bf00431684
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发表时间：
1985
影响因子：
3.4
通讯作者：
Shaughnessy,RA
中科院分区：
文献类型：
--
作者：
Seiden,LS;Dahms,JL;Shaughnessy,RA
那些在临床广泛使用的抗抑郁药物，当给大鼠进行低率72-s （DRL 72-s）的差异强化时，会降低反应率，增加强化率。非抗抑郁药没有这种效果。在本实验中，研究了以下药物对DRL 72-s时间表的影响：tranzodone、zimelidine、氟西汀和安非他酮（非典型抗抑郁药）；电休克（ECS，这是一种治疗抑郁症的有效方法）；氟哌啶醇和氯氮平（抗精神病药物）。曲唑酮（3.12-25.00 mg/kg）、氟西汀（10-20 mg/kg）和ECS降低了应答率，增加了强化率。Zimelidine （20 mg/kg）增加了强化率，但没有显著降低反应率。在2.5 ~ 40 mg/kg剂量下，安非他酮对强化率和反应率没有影响，但在60 mg/kg剂量下，反应率增加，强化率无显著降低。在高剂量下，安非他酮的作用类似于精神运动兴奋剂。氟哌啶醇（0.04 mg/kg）和氯氮平（2.5 ~ 10.0 mg/kg）降低了应答率和强化率。这些结果表明，DRL 72-s表可能有助于测试新药的抗抑郁潜力。
Those antidepressant drugs that are, in wide clinical use decrease response rate and increase reinforcement rate when administered to rats performing on a differential-reinforcement-of-low-rate 72-s (DRL 72-s) schedule. Drugs that are not antidepressants do not have this effect. In this experiment, the following were examined for their effects on a DRL 72-s schedule: tranzodone, zimelidine, fluoxetine, and bupropion (atypical antidepressants); electroconvulsive shock (ECS, which is an effective treatment for depression); and haloperidol and clozapine (antipsychotic drugs). Trazodone (3.12–25.00 mg/kg), fluoxetine (10–20 mg/kg), and ECS decreased response rate and increased reinforcement rate. Zimelidine (20 mg/kg) increased reinforcement rate and nonsignificantly decreased response rate. At doses between 2.5 and 40 mg/kg, bupropion had no effect on reinforcement rate or response rate, but at 60 mg/kg response rate was increased and reinforcement rate was nonsignificantly decreased. At the higher dose, the effects of bupropion resemble those of a psychomotor stimulant. Haloperidol (0.04 mg/kg) and clozapine (2.5–10.0 mg/kg) decreased response rate and reinforcement rate. These results, suggest that the DRL 72-s schedule may be useful for testing the antidepressant potential of new drugs.