TLR signaling.
TLR signaling.
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DOI：
10.1007/3-540-32636-7_1
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发表时间：
2006
影响因子：
12.4
通讯作者：
T. Kawai;S. Akira
中科院分区：
文献类型：
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作者：
T. Kawai;S. Akira
哺乳动物Toll样受体（TLR）在检测入侵病原体以及触发随后的炎症和免疫应答中起关键作用。每个TLR识别不同的微生物组分，并通过选择性利用接头分子激活不同的信号传导途径。通过TLR的信号传导从细胞表面和/或内体递送。最近，在哺乳动物中也发现了胞质内微生物检测系统。肽聚糖分解产物和双链RNA分别被NOD家族和RNA解旋酶结构域蛋白所感知。因此，哺乳动物利用受体型和细胞内蛋白作为入侵病原体的检测器。
Mammalian Toll-like receptors (TLRs) play a critical role in detection of invading pathogens as well as triggering of subsequent inflammatory and immune responses. Each TLR recognizes distinct microbial components and activates different signaling pathways by selective utilization of adaptor molecules. The signaling via TLRs is delivered from the cell surface and/or the endosome. Recently, the intracytoplasmic detection system of microbes has been identified in mammals as well. Peptidoglycan breakdown products and double-stranded RNA are sensed by NOD family and RNA helicase domain containing proteins, respectively. Thus, mammals make use of both receptor-type and intracellular proteins as detectors of invading pathogens.