Leptin responses to long-term cardiorespiratory exercise training without concomitant weight loss: a prospective study.
Leptin responses to long-term cardiorespiratory exercise training without concomitant weight loss: a prospective study.
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发表时间：
2008-09
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通讯作者：
J. Lowndes;R. Zoeller;J. D. Caplan;G. Kyriazis;N. Moyna;R. Seip;P. Thompson;T. Angelopoulos
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作者：
J. Lowndes;R. Zoeller;J. D. Caplan;G. Kyriazis;N. Moyna;R. Seip;P. Thompson;T. Angelopoulos
目的：本研究的目的是检查1）是否循环瘦素水平的变化发生在6个月的有氧运动训练（ET）没有伴随体重减轻; 2）是否有不同的反应，就性别而言;和3）年龄和瘦素之间的关系，以及这种关系是否有任何影响ET没有减肥的反应。方法：38名健康、久坐的男性和女性（年龄38.43 ± 2.24，范围18-59岁）参加了为期6个月的监督性中等强度（ET）治疗，每周进行4天。鼓励维持通常的饮食习惯，以尽量减少体重减轻。在ET前后评估参与者的循环空腹瘦素、体重、体脂百分比和最大有氧功率（VO 2 max）。结果体重和瘦素浓度没有降低（17.69+/-2.67 vs 16.85+/-3.12 ng dL（-1））。性别不影响运动训练的反应。瘦素与年龄的双变量相关性不显著，但在控制体脂百分比和VO 2 max后，相关性达到显著水平（r =-0.358，P < 0.05）。年龄不影响瘦素浓度对ET的反应。结论：以前报道的ET引起的瘦素浓度变化可能与体重减轻有关，但年龄在瘦素对ET的反应中不起作用。
AIM The aims of the present study were to examine 1) whether changes in circulating leptin levels occur in response to six months of aerobic exercise training (ET) without concomitant weight loss; 2) whether there is a different response with respect to gender; and 3) the relationship between age and leptin and whether this relationship has any impact on the response to ET without weight-loss. METHODS Thirty-eight healthy, sedentary men and women (age 38.43+/-2.24, range 18-59 years) participated in 6 months of supervised, moderate intensity (ET) performed 4 days per week. Maintenance of usual dietary practices were encouraged to minimize weight-loss. Participants were evaluated for circulating fasting leptin, body mass, body fat percentage and maximal aerobic power (VO2max) prior to and after ET. RESULTS There was no decrease in body weight or leptin concentration (17.69+/-2.67 vs 16.85+/-3.12 ng dL(-1)). Gender did not affect the response to exercise training. The bivariate correlation between leptin and age was not significant, but the relationship reached significance after controlling for body fat percentage and VO2max (r = -0.358, P < 0.05). Age did not affect the response of leptin concentration to ET. CONCLUSION It is probable that changes in leptin concentration reported previously with ET may be attributable to concomitant weight loss, but age does not play a role in how leptin responds to ET.