Viral strategies of immune evasion
Viral strategies of immune evasion
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DOI：
10.1126/science.280.5361.248
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发表时间：
1998-04-10
期刊：
影响因子：
56.9
通讯作者：
Ploegh, HL
中科院分区：
文献类型：
--
作者：
Ploegh, HL
脊椎动物体内是病毒理想的滋生地，提供了促进其生长、生存和传播的条件。免疫系统进化并应对这一挑战。相互确保毁灭并不是可行的进化策略；因此，宿主-病毒相互作用的研究不仅提供了免疫边缘生命的一瞥，而且还阐明了免疫系统的基本功能，特别是主要组织相容性复合物限制性抗原呈递的区域。
The vertebrate body is an ideal breeding ground for viruses and provides the conditions that promote their growth, survival, and transmission. The immune system evolved and deals with this challenge. Mutually assured destruction is not a viable evolutionary strategy; thus, the study of host-virus interactions provides not only a glimpse of life at immunity's edge, but it has also illuminated essential functions of the immune system, in particular, the area of major histocompatibility complex-restricted antigen presentation.