BRONCHIAL RESPONSIVENESS TO MITE ALLERGEN IN ATOPIC-DERMATITIS WITHOUT ASTHMA
BRONCHIAL RESPONSIVENESS TO MITE ALLERGEN IN ATOPIC-DERMATITIS WITHOUT ASTHMA
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DOI：
10.1159/000235204
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发表时间：
1990-06-01
期刊：
影响因子：
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通讯作者：
MIYAMOTO, T
中科院分区：
文献类型：
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作者：
DOHI, M;OKUDAIRA, H;MIYAMOTO, T
8例无哮喘发作史的特应性皮炎（AD）患者和8例螨过敏性支气管哮喘（BA）患者接受了非特异性刺激（乙酰胆碱）和免疫特异性刺激（屋尘螨过敏原）的支气管吸入激发。AD患者血清IgE（p < 0.01）和抗IgE抗体（p < 0.05）均显著高于BA患者。AD患者的非特异性支气管高反应性分布在正常至哮喘范围内。过敏原激发后，所有8例AD患者和所有8例BA患者均表现出立即哮喘反应（IAR）。AD患者中诱导IAR的螨提取物浓度显著（p < 0.01）高于BA患者。在8例BA患者中的6例中观察到晚期哮喘反应，而在任何AD患者中均未观察到。我们的研究结果表明，AD患者是一个特定的螨过敏原的反应比BA患者，尽管更高浓度的抗螨IgE抗体。他们认为支气管对变应原反应性的差异与临床症状发作的差异有关，并且一定水平的支气管对变应原的高反应性是哮喘症状发展的先决条件。
Eight patients with atopic dermatitis (AD) without a history of asthmatic episodes and 8 patients with mite-allergic bronchial asthma (BA) were subjected to bronchial inhalation challenge with a nonspecific stimulus (acetylcholine) and an immunologically specific stimulus (house dust mite allergen). AD patients had a significantly greater concentration of IgE (p < 0.01) and antimite IgE antibody (p < 0.05) than BA patients. Nonspecific bronchial hyperreactivities of AD patients distributed from normal to asthmatic range. After allergen challenge, all 8 AD patients and all 8 BA patients showed an immediate asthmatic response (IAR). The mite extract concentration to induce an IAR was significantly (p < 0.01) greater in AD patients than in BA patients. A late asthmatic response was observed in 6 out of 8 BA patients, whereas it was not observed in any AD patient. Our results showed that AD patients are less reactive to a specific mite allergen than BA patients in spite of greater concentrations of antimite IgE antibody. They suggest that this difference in the bronchial reactivity to the allergen concerns the difference in the onset of clinical symptoms and that a certain level of bronchial hyperreactivity to the allergen is a prerequisite for the development of asthmatic symptoms.