A facile direct anti-selective catalytic asymmetric Mannich reaction of aldehydes with preformed N-Boc and N-Cbz imines.
A facile direct anti-selective catalytic asymmetric Mannich reaction of aldehydes with preformed N-Boc and N-Cbz imines.
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DOI：
10.1039/c0cc05249c
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发表时间：
2011-03
影响因子：
4.9
通讯作者：
Y. Chuan;Guihua Chen;Jiuzhi Gao;H. Zhang;Yungui Peng
中科院分区：
文献类型：
--
作者：
Y. Chuan;Guihua Chen;Jiuzhi Gao;H. Zhang;Yungui Peng
在仲胺-硫脲催化剂的催化下，N-Boc和N-Cbz保护的亚胺与未修饰的醛的反选择性曼尼希反应顺利进行，在常规有机合成操作下实现了高收率（70%-95%）和优异的对映选择性（高达96:4 dr和>99% ee）。
Anti-selective Mannich reactions of N-Boc and N-Cbz protected imines with unmodified aldehydes proceeded smoothly under the catalysis of a secondary amine-thiourea catalyst, which led to high yields (70%-95%) and excellent enantioselectivity (up to 96 : 4 dr and >99% ee) under conventional organic synthetic operations.