Low frequency of human papillomavirus DNA in breast cancer tissue
Low frequency of human papillomavirus DNA in breast cancer tissue
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DOI：
10.1007/s10549-008-9989-1
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发表时间：
2009-03-01
影响因子：
3.8
通讯作者：
Montoya-Fuentes, H.
中科院分区：
文献类型：
--
作者：
Mendizabal-Ruiz, A. P.;Morales, J. A.;Montoya-Fuentes, H.
人乳头瘤病毒（HPV）是宫颈癌的主要病原体。几份报告已经讨论了HPV和乳腺癌的关系，因为已经确定了不同的HPV。采用聚合酶链反应（PCR）技术，对67例乳腺癌患者和40例非恶性乳腺疾病患者的乳腺组织进行HPV DNA检测。病例组HPV阳性率为4.4%（3/67），对照组未检出HPV阳性。3例阳性标本经酶切和直接测序鉴定为HPV 16、18和33型。相关研究中检测结果的高度多样性表明群体基因组异质性在该病中起着重要作用。本研究中检测到的低频率表明HPV在乳腺癌中不起重要作用。
Human papillomavirus (HPV) is considered the aetiological agent for cervical cancer. Several reports have addressed a relationship with HPV and breast cancer, as different HPVs have been identified. The purpose of this study was to detect HPV DNA in 67 breast cancer patients and 40 non-malignant disease breast tissues by means of Polymerase Chain Reaction with consensus primers. The frequency of HPV in the cases group were 4.4% (3/67) and no positive samples among the reference group were identified. From the 3 positive samples, HPV types 16, 18 and 33 were identified by restriction patterns and direct sequencing. The high diversity among detection in the related studies shows that population genomic heterogeneity plays an important role in the disease. The low frequency detected in the present study suggests that HPV does not play an important role in breast cancer.