EFFECTS OF OVERFEEDING ON CARBOHYDRATE-TOLERANCE, INSULIN-SECRETION, ESTERIFICATION AND LIPOLYSIS IN HEALTHY SUBJECTS
EFFECTS OF OVERFEEDING ON CARBOHYDRATE-TOLERANCE, INSULIN-SECRETION, ESTERIFICATION AND LIPOLYSIS IN HEALTHY SUBJECTS
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DOI：
10.1055/s-0028-1093430
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发表时间：
1978-01-01
影响因子：
2.2
通讯作者：
GOLDRICK, RB
中科院分区：
文献类型：
--
作者：
CHINAYON, S;GOLDRICK, RB
Blood glucose, plasma concentrations of insulin, free fatty acids (FFA) and glycerol were measured in 11 healthy lean young adults, in response to a standard high carbohydrate meal, before and during overfeeding with a high carbohydrate or a high fat diet. The plasma insulin was unaffected by overfeeding, while the hypercaloric high carbohydrate diet enhanced carbohydrate tolerance and the hypercaloric high fat diet had the reverse effect. Both types of overfeeding depressed the postabsorptive and absorptive concentrations of plasma FFA. Overfeeding with the high carbohydrate diet had no effect on the plasma glycerol concentrations recorded before and after ingestion of the standard breakfast. Overfeeding with high fat diet also failed to alter the postabsorptive concentration of plasma glycerol but the plasma glycerol levels rose following the standard high carbohydrate meal. Apparently overfeeding with a high carbohydrate diet enhances the utilization of glucose by increasing sensitivity to insulin, while overfeeding with a high fat diet has the opposite effect; esterification of FFA in adipose tissue is stimulated by overfeeding independently of the composition of the diet and basal lipolysis in adipose tissue as judged by the postabsorptive plasma glycerol concentrations is unaffected by overfeeding but the antilipolytic effects of insulin on adipose tissue appear to be impaired following the standard meal, when subjects are overfed with a high fat diet.
