Ovarian neoplasm development by 7,12-dimethylbenz[a]anthracene (DMBA) in a chemically-induced rat model of ovarian failure.
Ovarian neoplasm development by 7,12-dimethylbenz[a]anthracene (DMBA) in a chemically-induced rat model of ovarian failure.
复制标题
DOI：
10.1016/j.ygyno.2008.12.013
复制
发表时间：
2009-03
影响因子：
4.7
通讯作者：
Brewer, M. A.
中科院分区：
文献类型：
--
作者：
Hoyer, P. B.;Davis, J. R.;Bedrnicek, J. B.;Marion, S. L.;Christian, P. J.;Barton, J. K.;Brewer, M. A.
关键词：
The objectives were to determine the time course for ovarian failure in rats caused by 4-vinylcyclohexene diepoxide (VCD) and develop a model for ovarian cancer in which ovarian neoplasms were chemically induced in an animal that was follicle depleted, but retained residual ovarian tissue. Initially, female Fisher 344 rats were treated with VCD (to induce ovarian failure) or vehicle control (sesame oil). Three or six months after treatment ovaries were collected and processed for histological evaluation for confirmation of ovarian failure. A further set of female rats was assigned to four groups exposed to combinations of vehicle control, VCD and/or DMBA (directly applied to the ovary) in a novel model for examining early stages of ovarian neoplasia. Three and six months following VCD dosing there was a significant reduction of ovarian weight and follicle number. Treatment with DMBA subsequent to VCD resulted in tumors in 42% of animals at three months and 57% at five months. All neoplasms were classified Sertoli-Leydig cell tumors (SLCT). No tumors occurred in animals treated with vehicle or DMBA alone. These studies demonstrate that the VCD-treated rat can be used as a model for peri- and post-menopause. DMBA induction of ovarian neoplasms was greater in those rats treated with VCD. Whether this increase was due to tumor initiation by VCD or was the result of ovarian failure cannot be distinguished from these results. This represents the only animal model to date for sex cord stromal tumors.
登录
查看更多内容
影响因子：
3.6
作者：
Mayer, LP;Devine, PJ;Hoyer, PB
通讯作者：
Hoyer, PB
影响因子：
3.6
作者：
Hu, XM;Christian, PJ;Hoyer, PB
通讯作者：
Hoyer, PB
DOI：
10.1097/01.gme.0000191883.59799.2e
发表时间：
2006-05-01
影响因子：
2.7
作者：
Lohff, Jessica C.;Christian, Patricia J.;Hoyer, Patricia B.
通讯作者：
Hoyer, Patricia B.
影响因子：
3.6
作者：
Hu, XM;Flaws, JA;Hoyer, PB
通讯作者：
Hoyer, PB
影响因子：
6.4
作者：
KRARUP, T
通讯作者：
KRARUP, T