Experience-specific functional modification of the dentate gyrus through adult neurogenesis: A critical period during an immature stage
Experience-specific functional modification of the dentate gyrus through adult neurogenesis: A critical period during an immature stage
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DOI：
10.1523/jneurosci.4941-06.2007
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发表时间：
2007-03-21
影响因子：
5.3
通讯作者：
Gage, Fred H.
中科院分区：
文献类型：
--
作者：
Tashiro, Ayumu;Makino, Hiroshi;Gage, Fred H.
齿状回中的神经回路被成年神经发生持续地修改，其水平受到动物经验的影响。然而，目前尚不清楚这种经验依赖性的解剖学修改是否会改变齿状回的功能特性。在这里，使用立即早期基因产物，c-fos和Zif 268的表达，作为最近激活的神经元的指标，我们表明，以前暴露于丰富的环境增加了新的神经元的总数和新的神经元的数量响应重新暴露于相同的环境。激活的新神经元密度的增加是对暴露于相同环境而不是不同经历的反应。此外，我们发现，这些经验特定的修改只受以前的曝光后第二周左右，神经元出生，但不迟于3周。因此，动物在新神经元的未成熟阶段期间的关键时期内的经验决定了新神经元的存活和群体反应，并且可能影响齿状回中的经验的后期神经表征。这种通过成年神经发生的经验特异性功能修饰可能是新神经元对与学习和记忆相关的齿状回功能产生长期影响的机制。
Neural circuits in the dentate gyrus are continuously modified by adult neurogenesis, whose level is affected by the animal's experience. However, it is not known whether this experience-dependent anatomical modification alters the functional properties of the dentate gyrus. Here, using the expression of immediate early gene products, c-fos and Zif268, as indicators of recently activated neurons, we show that previous exposure to an enriched environment increases the total number of new neurons and the number of new neurons responding to reexposure to the same environment. The increase in the density of activated new neurons occurred specifically in response to exposure to the same environment but not to a different experience. Furthermore, we found that these experience-specific modifications are affected exclusively by previous exposure around the second week after neuronal birth but not later than 3 weeks. Thus, the animal's experience within a critical period during an immature stage of new neurons determines the survival and population response of the new neurons and may affect later neural representation of the experience in the dentate gyrus. This experience-specific functional modification through adult neurogenesis could be a mechanism by which new neurons exert a long-term influence on the function of the dentate gyrus related to learning and memory.