Divalproex in posttraumatic stress disorder:: An open-label clinical trial
Divalproex in posttraumatic stress disorder:: An open-label clinical trial
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DOI：
10.1023/a:1024797014210
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发表时间：
1999-04-01
影响因子：
3.3
通讯作者：
Tuason, VB
中科院分区：
文献类型：
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作者：
Clark, RD;Cañive, JM;Tuason, VB
创伤后应激障碍(PTSD)以侵扰、回避和过度唤醒症状为特征。本研究旨在探讨异丙丙胺在减轻创伤后应激障碍患者的症状、抑郁和焦虑方面的有效性。在阿尔伯克基VAMC门诊创伤后应激障碍治疗计划中，16名被诊断为DSM-IV的创伤后应激障碍患者接受了Divalproex的所有开放标签试验。患者在基线和8周时由训练有素的评分员使用临床医生应用的创伤后应激障碍量表(CAPS)、汉密尔顿抑郁量表(HAM-D)和汉密尔顿焦虑量表(HAM-A)进行评估。在治疗后8周的评估中测量丙戊酸的血浆浓度。三名患者因正弦效应而停止服药。侵扰和过度觉醒症状显著减少，而回避/麻木症状没有明显变化。由HAM-D测量的抑郁症状在治疗后的评估中出人意料地减少。HAM-A得分也显著下降。需要进行对照试验来进一步研究异丙丙胺治疗创伤后应激障碍的疗效。
Posttraumatic stress disorder (PTSD) is characterized by intrusive, avoidance, and hyperarousal symptoms. This study was conducted to investigate the effectiveness of divalproex in reducing PTSD symptoms, depression, and anxiety in patients,vith PTSD. Sixteen patients with a DSM-IV diagnosis of PTSD at the Albuquerque VAMC outpatient PTSD treatment program received all open-label trial of divalproex. The patients were evaluated at baseline and at 8 weeks by a trained rater using the Clinician Administered PTSD Scale (CAPS), the Hamilton Rating Scale for Depression (HAM-D) and the Hamilton Rating Scale for Anxiety (HAM-A). Plasma valproate levels were measured at the 8-week post-treatment assessment. Three patients stopped the medications due to sine effects. Intrusion and hyperarousal symptoms decreased significantly, while no significant change was seen in avoidance/numbing symptoms. Depressive symptoms, as measured by the HAM-D, unexpectedly decreased at post-treatment assessment. HAM-A scores also decreased significantly. Controlled trials are needed to further study the efficacy of divalproex in the treatment of PTSD.