Affective lability and affect intensity as core dimensions of bipolar disorders during euthymic period
Affective lability and affect intensity as core dimensions of bipolar disorders during euthymic period
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DOI：
10.1016/j.psychres.2005.11.016
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发表时间：
2008-05-30
影响因子：
11.3
通讯作者：
Leboyer, Marion
中科院分区：
文献类型：
--
作者：
Henry, Chantal;Van den Bulke, Donatienne;Leboyer, Marion
双相情感障碍通常由不同的情绪状态定义，但对正常情绪期的更精确描述可以为双相情感障碍的病理生理学提供进一步的见解。令人惊讶的是，很少有研究调查了情感正常的双相情感障碍患者的核心情感维度。在这项研究中，我们评估了179名情感正常的双相情感障碍患者（蒙哥马利-阿斯伯格抑郁量表评分< 12分，Bech-Rafaelsen躁狂量表评分< 6分），并与86名对照受试者进行了比较，使用法国版本的情感不稳定量表（ALS）和情感强度测量（AIM）。资料采用Logistic回归分析。我们的研究结果表明，情绪正常的双相情感障碍者比对照组有更强烈的情绪，也有更高的情感不稳定性。两个情感维度的高分与精神轴I共病的风险显著增高相关。此外，高情感不稳定性评分与双相情感障碍的早期发病年龄相关。情感不稳定性和情感强度可能是双相情感障碍的两个核心维度，在心境正常时期，这表明双相情感障碍不仅限于情绪发作，而且还影响发作之间的情绪反应。这两个维度都可以解释双相情感障碍患者可能导致复发的应激反应。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
Bipolar disorders are usually defined by alternative mood states, but a more precise characterization of the euthymic period could provide further insights into the pathophysiology of bipolar disorders. Surprisingly, few studies have investigated core affective dimensions in euthymic bipolar patients. In this study, we assessed 179 euthymic bipolar patients (score < 12 on the Montgomery-Asberg Depression Scale and a score < 6 on the Bech-Rafaelsen Mania Scale) compared with 86 control subjects using French versions of the Affective Lability Scale (ALS) and the Affect Intensity Measure (AIM). Data were analyzed by logistic regression. Our results showed that euthymic bipolar subjects reported having more intense emotions than controls and also had a higher affective lability. High scores in both affective dimensions were associated with a significantly higher risk for psychiatric axis I comorbidity. Moreover, a high affective lability score was associated with an earlier age of onset for bipolar disease. Affective lability and affect intensity might be two core dimensions of bipolar disorder during euthymic periods, suggesting that bipolar disorder is not circumscribed to mood episodes but also affects emotional reactivity between episodes. Both dimensions could account for the stress reactivity of bipolar patients that may lead to relapses. (c) 2007 Elsevier Ireland Ltd. All rights reserved.