The role of the calcium-sensing receptor in epidermal differentiation
The role of the calcium-sensing receptor in epidermal differentiation
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DOI：
10.1016/j.ceca.2003.10.019
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发表时间：
2004-03-01
期刊：
影响因子：
4
通讯作者：
Bikle, DD
中科院分区：
文献类型：
--
作者：
Tu, CL;Oda, Y;Bikle, DD
钙在体内和体外调节角质形成细胞的增殖和分化。细胞外 Ca2+ 浓度 ([Ca2+](o)) 升高会增加细胞内游离钙 ([Ca2+](i)) 并激活分化相关基因。缺乏钙敏感受体 (CaR) 的细胞无法响应 [Ca2+](o) 并分化，表明 CaR 在角质形成细胞分化中的作用。这些源自体外实验的概念已在两种小鼠模型中得到测试和证实。 (C) 2003 Elsevier Ltd. 保留所有权利。
Calcium regulates the proliferation and differentiation of keratinocytes both in vivo and in vitro. Elevated extracellular Ca2+ concentration ([Ca2+](o)) raises the intracellular free calcium ([Ca2+](i)) and activates differentiation-related genes. Cells lacking the calcium-sensing receptor (CaR) fail to respond to [Ca2+](o) and to differentiate, indicating a role for CaR in keratinocyte differentiation. These concepts derived from in vitro experiments have been tested and confirmed in two mouse models. (C) 2003 Elsevier Ltd. All rights reserved.