Multiple newly identified loci associated with prostate cancer susceptibility
Multiple newly identified loci associated with prostate cancer susceptibility
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DOI：
10.1038/ng.90
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发表时间：
2008-03-01
期刊：
影响因子：
30.8
通讯作者：
Easton, Douglas F.
中科院分区：
文献类型：
--
作者：
Eeles, Rosalind A.;Kote-Jarai, Zsofia;Easton, Douglas F.
前列腺癌是发达国家男性最常见的癌症。它显示了一致的家庭聚集的证据，但这种聚集的原因大多是未知的。为了确定与前列腺癌风险相关的常见等位基因，我们进行了一项全基因组关联研究(Gwas)，使用了1,854名临床诊断为前列腺癌的患者的血液DNA样本。
Prostate cancer is the most common cancer affecting males in developed countries. It shows consistent evidence of familial aggregation, but the causes of this aggregation are mostly unknown. To identify common alleles associated with prostate cancer risk, we conducted a genome-wide association study (GWAS) using blood DNA samples from 1,854 individuals with clinically detected prostate cancer diagnosed at