A second amplifier function for the allergy-associated FcεRI-β subunit
A second amplifier function for the allergy-associated FcεRI-β subunit
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DOI：
10.1016/s1074-7613(00)80203-4
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发表时间：
2000-05-01
期刊：
影响因子：
32.4
通讯作者：
Kinet, JP
中科院分区：
文献类型：
--
作者：
Donnadieu, E;Jouvin, MH;Kinet, JP
遗传学研究已经确定了高亲和力IgE受体（Fc β RI）β亚基的基因作为特应性的候选基因。我们已经表明，β是一种内在的信号放大器，导致增强过敏反应在体内。在这里，我们报告说，β有第二个放大功能：放大Fc β RI细胞表面表达。这种功能是由于β与α的早期结合，导致α和受体复合物的运输和成熟得到改善。这些数据为β（-）细胞（如单核细胞、树突状细胞）和β（+）效应细胞（肥大细胞、嗜碱性粒细胞）之间Fc γ RI密度的巨大差异提供了可能的分子解释。在β（+）细胞中，组合的信号传导和表达扩增导致下游事件的估计12至30倍扩增。
Genetics studies have identified the gene for the high-affinity IgE receptor (Fc epsilon RI) beta subunit as a candidate gene for atopy. We have shown that beta is an intrinsic signaling amplifier leading to enhanced allergic responses in vivo. Here we report that beta has a second amplification function: the amplification of Fc epsilon RI cell surface expression. This function is due to an early association of beta with alpha, resulting in improved trafficking and maturation of alpha and receptor complexes. These data provide a possible molecular explanation for the large difference in Fc epsilon RI density between beta(-)cells such as monocytes, dendritic cells, and beta(+) effector cells (mast cells, basophils). In beta(+) cells, the combined signaling and expression amplification results in an estimated 12- to 30-fold amplification of downstream events.