Molecular-length and chiral discriminations by beta-structural poly(L-alanine) on silica.
Molecular-length and chiral discriminations by beta-structural poly(L-alanine) on silica.
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DOI：
10.1016/j.chroma.2004.08.062
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发表时间：
2005-05
期刊：
影响因子：
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通讯作者：
A. Shundo;T. Sakurai;M. Takafuji;S. Nagaoka;H. Ihara
中科院分区：
文献类型：
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作者：
A. Shundo;T. Sakurai;M. Takafuji;S. Nagaoka;H. Ihara
以3-氨丙基化二氧化硅为引发剂，通过L-丙氨酸的N-羧酸酐聚合制备了聚L-丙氨酸接枝多孔二氧化硅（Sil-Ala 22）。用SiI-Ala 22填充柱的液相色谱保留时间评价了它与芳香客体分子的选择性相互作用。SiL-Ala 22对分子长度、线性和平面性等分子形状具有特异的选择性保留。这种选择性可以通过与肽主链中刚性β-型结构上一维排列的羰基的多π-π相互作用来解释。同时也描述了SiL-Ala 22对手性的拆分。
Poly(l-alanine)-grafted porous silica (Sil-Ala22) was prepared by polymerization of N-carboxyanhydride of l-alanine initiated by 3-aminopropylated silica. Its selective interaction with aromatic guest molecules was evaluated by the retention time in liquid chromatography using the column packed with Sil-Ala22. Sil-Ala22showed a specific selective retention with discriminating molecular shapes, such as molecular length, linearity and planarity. This selectivity can be explained by a multiple π–π interaction with the carbonyl groups one dimensionally-aligned on the rigid β-form structure in the peptide main chain. Chiral separation with Sil-Ala22was also described.