Safety factor for neuromuscular transmission at type-identified diaphragm fibers
Safety factor for neuromuscular transmission at type-identified diaphragm fibers
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DOI：
10.1002/mus.20751
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发表时间：
2007-06-01
期刊：
影响因子：
3.4
通讯作者：
Sieck, Gary C.
中科院分区：
文献类型：
--
作者：
Ermilov, Leonid G.;Mantilla, Carlos B.;Sieck, Gary C.
神经肌肉传递的安全系数（SF）在不同纤维类型组成的肢体肌肉中各不相同。使用大鼠膈肌纤维的细胞内记录，我们发现SF在不同的肌纤维类型（即使在一个单一的肌肉），II型或IIb型纤维大于I型或IIa型纤维。激活历史或机械负荷的纤维类型差异可能导致SF的差异，并且是神经肌肉可塑性的重要决定因素。
The safety factor (SF) for neuromuscular transmission varies across limb muscles of different fiber-type composition. Using intracellular recordings in rat diaphragm fibers, we found that SF varies across muscle fiber types (even within a single muscle), being larger for type II or IIb fibers than for type I or IIa fibers. Fiber-type differences in activation history or mechanical load may contribute to differences in SF and are important determinants of neuromuscular plasticity.