Metabolic effects of intravenous LCT or MCT/LCT lipid emulsions in preterm infants
Metabolic effects of intravenous LCT or MCT/LCT lipid emulsions in preterm infants
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DOI：
10.1194/jlr.m500423-jlr200
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发表时间：
2006-02-01
影响因子：
6.5
通讯作者：
Koletzko, B
中科院分区：
文献类型：
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作者：
Lehner, F;Demmelmair, H;Koletzko, B
用于早产儿胃肠外喂养的大多数脂肪乳剂基于长链三酰甘油（LCT），但包含中链三酰甘油（MCT）可能提供更容易氧化的能量来源。在12名早产新生儿中研究了这些乳剂对脂肪酸组成和代谢的影响，这些新生儿被随机分配至LCT乳剂（对照）或MCT和LCT混合乳剂（1：1）组。在研究第7天，所有婴儿口服[C-13]亚油酸（LA）和[C-13] α-亚麻酸（ALA）示踪剂。在第8天测定血浆磷脂（PL）和三酰甘油（TG）脂肪酸组成以及血浆PL脂肪酸的C-13富集。8天脂质输注后，MCT/LCT组的血浆TG含量高于对照组的C8：0（0.50 +/- 0.60% vs. 0.10 +/- 0.12%;平均值+/- SD）和C10：0（0.66 +/- 0.51% vs. 0.15 +/- 0.17%）。MCT/LCT组血浆PL中的LA含量略低（16.47 +/- 1.16% vs. 18.57 +/- 2.09%），而LA和ALA的长链多不饱和衍生物（LC-PUFA）往往较高。前体和产物（LC-PUFA）之间的示踪剂分布在组间无显著差异。两种脂肪乳剂的血浆必需脂肪酸（EFA）含量相似，EFA向LC-PUFA的转化比例相似。MCT/LCT乳剂似乎可保护EFA和LC-PUFA免受β-氧化。莱纳，F.，H. Demmelmair，W. Roschinger，T. Decsi，M.萨斯，K.阿达莫维奇河Arnecke和B.科莱茨科静脉注射LCT或MCT/LCT脂肪乳剂对早产儿的代谢影响。
Most lipid emulsions for parenteral feeding of premature infants are based on long-chain triacylglycerols (LCTs), but inclusion of medium-chain triacylglycerols (MCTs) might provide a more readily oxidizable energy source. The influence of these emulsions on fatty acid composition and metabolism was studied in 12 premature neonates, who were randomly assigned to an LCT emulsion (control) or an emulsion with a mixture of MCT and LCT (1: 1). On study day 7, all infants received [C-13] linoleic (LA) and [C-13] alpha-linolenic acid (ALA) tracers orally. Plasma phospholipid (PL) and triacylglycerol (TG) fatty acid composition and C-13 enrichments of plasma PL fatty acids were determined on day 8. After 8 days of lipid infusion, plasma TGs in the MCT/LCT group had higher contents of C8:0 (0.50 +/- 0.60% vs. 0.10 +/- 0.12%; means +/- SD) and C10:0 (0.66 +/- 0.51% vs. 0.15 +/- 0.17%) than controls. LA content of plasma PLs was slightly lower in the MCT/LCT group (16.47 +/- 1.16% vs. 18.57 +/- 2.09%), whereas long- chain polyunsaturated derivatives (LC-PUFAs) of LA and ALA tended to be higher. The tracer distributions between precursors and products (LC-PUFAs) were not significantly different between groups. Both lipid emulsions achieve similar plasma essential fatty acid (EFA) contents and similar proportional conversion of EFAs to LC-PUFAs. The MCT/LCT emulsion seems to protect EFAs and LC-PUFAs from beta-oxidation.-Lehner, F., H. Demmelmair, W. Roschinger, T. Decsi, M. Szasz, K. Adamovich, R. Arnecke, and B. Koletzko. Metabolic effects of intravenous LCT or MCT/LCT lipid emulsions in preterm infants.