Role of immunophilins in recovery of erectile function after cavernous nerve injury.
Role of immunophilins in recovery of erectile function after cavernous nerve injury.
复制标题
DOI：
10.1111/j.1743-6109.2008.01193.x
复制
发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Burnett AL
中科院分区：
文献类型：
--
作者：
Sezen SF;Lagoda G;Burnett AL
Immunophilin ligands provide potentially new alternatives for the treatment of erectile dysfunction (ED) which occurs after injury of the cavernous nerves (CN). To review and update current knowledge of the neurotrophic effects and likely mechanism of action of immunophilin proteins with emphasis on the FK506-binding protein (FKBP) subfamily and the role of immunophilin ligands for the treatment of CN injury induced ED. Review of available reports of studies investigating the effects and neurotrophic mechanisms of immunophilin ligands involved in erectile function recovery in rodent models of CN injury. Erection parameters and molecular correlations associated with CN injury and functional recovery. Treatment with prototype immunosuppressive immunophilin ligands FK506 (FK) and Rapamycin (Rapa) improve erectile function in animal models of CN injury. Similarly, non-immunousuppressive analogs such as GPI-1046 and FK1706 are effective in recovery of erections after CN injury. Neuronal nitric oxide may influence the erection recovery effects of immunophilin ligands after CN injury. FKBPs 38 and 65 expression changes in the penis and its innervation coincide with the neurotrophic effects of immunophilin ligands. Antioxidative actions of immunophilin ligands contribute to their neurotrophic effects. Immunophilins are localized to nerves coursing in human prostate and penile tissue. The findings support the hypothesis that immunophilin ligands, working through specific receptor mechanisms which are specific to injured CN, are potentially useful to sustain erectile function in men following radical prostatectomy.
登录
查看更多内容
影响因子：
3.5
作者：
Bella, Anthony J.;Hayashi, Narihiko;Lue, Tom F.
通讯作者：
Lue, Tom F.
DOI：
10.1016/j.biocel.2004.03.013
发表时间：
2005-01-01
影响因子：
4
作者：
Davies, TH;Sánchez, ER
通讯作者：
Sánchez, ER
影响因子：
6.6
作者：
Burnett, AL;Becker, RE
通讯作者：
Becker, RE
影响因子：
11.4
作者：
Edlich, F;Weiwad, M;Fischer, G
通讯作者：
Fischer, G
DOI：
10.1016/j.bbrc.2005.09.023
发表时间：
2005-11-11
影响因子：
3.1
作者：
Kang, CB;Feng, L;Yoon, HS
通讯作者：
Yoon, HS