Role of 68Ga-DOTATOC PET-CT in the diagnosis and staging of pancreatic neuroendocrine tumours
Role of 68Ga-DOTATOC PET-CT in the diagnosis and staging of pancreatic neuroendocrine tumours
复制标题
DOI：
10.1007/s00330-011-2199-y
复制
发表时间：
2011-11-01
影响因子：
5.9
通讯作者：
Malhotra, Arun
中科院分区：
文献类型：
--
作者：
Kumar, Rakesh;Sharma, Punit;Malhotra, Arun
本研究的目的是评估 Ga-68-DOTA(0)-Phe(1)-Tyr(3)-奥曲肽 (Ga-68-DOTATOC) 正电子发射断层扫描计算机断层扫描 (PET-CT) 在胰腺神经内分泌肿瘤 (NET) 的检测和分期中的作用。20 名临床怀疑和/或组织病理学证实的胰腺 NET 患者接受了 Ga-68-DOTATOC PET-CT 成像用于原发病变的分期和/或定位。他们还接受了对比增强 CT (CECT)，其中 8 名患者接受了 F-18-FDG PET-CT。测量原发灶和转移灶的SUVmax。结果通过原发肿瘤的组织病理学和转移性疾病的临床随访/MRI 和/或活检进行验证。将 Ga-68-DOTATOC PET-CT 的结果与 CECT 和 F-18-FDG PET-CT 进行比较。Ga-68-DOTATOC PET-CT 在所有 20 例患者中正确定位原发灶，CECT 在 15 例中正确定位，F-18-FDG PET-CT 在 2 例中正确定位。 Ga-68-DOTATOC PET-CT 显示 13 名患者出现转移，CECT 报告 7 名患者，F-18-FDG PET-CT 报告 2 名患者。Ga-68-DOTATOC PET-CT 成为检测原发肿瘤和转移性疾病的最佳检查，具有 100% 的敏感性和 PPV。无论是原发灶（20vs.15）还是转移灶（13vs.7），CECT的检出率均低于Ga-68-DOTATOC PET-CT。 F-18-FDG PET-CT 对于原发灶和转移灶表现不佳。Ga-DOTATOC PET-CT 对于诊断和分期胰腺 NET 是一种非常有用的影像学检查。
The objective of the present study was to evaluate the role of Ga-68-DOTA(0)-Phe(1)-Tyr(3)-octreotide (Ga-68-DOTATOC) positron emission tomography computed tomography (PET-CT) for detection and staging of pancreatic neuroendocrine tumours (NETs).Twenty patients with clinically suspected and/or histopathologically proven pancreatic NET underwent Ga-68-DOTATOC PET-CT imaging for staging and /or localisation of primary lesion. They also underwent contrast enhanced CT (CECT) and 8 patients underwent F-18-FDG PET-CT. SUVmax of primary and metastatic lesions were measured. Results were verified with histopathology for primary tumour and with clinical follow up/MRI and /or biopsy for metastatic disease. Results of Ga-68-DOTATOC PET-CT were compared to CECT and F-18-FDG PET-CT.Ga-68-DOTATOC PET-CT correctly localised primary in all 20, CECT in 15 and F-18-FDG PET-CT in 2 patients. Ga-68-DOTATOC PET-CT demonstrated metastases in 13 patients, CECT in 7 and F-18-FDG PET-CT in 2. Ga-68-DOTATOC PET-CT emerged as the best investigation with 100% sensitivity and PPV for detecting primary tumour and metastatic disease. The detection rate of CECT was lower than Ga-68-DOTATOC PET-CT, both for primary tumour (20vs.15) or metastatic disease (13vs.7). F-18-FDG PET-CT performed poorly for primary and metastasis.Ga-DOTATOC PET-CT is a very useful imaging investigation for diagnosing and staging pancreatic NET.