Synthesis and biological evaluation of analogues of bacterial lipid I.
Synthesis and biological evaluation of analogues of bacterial lipid I.
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DOI：
10.1016/s0960-894x(00)00583-7
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发表时间：
2000-12
影响因子：
2.7
通讯作者：
D. J. Silva;C. Bowe;A. Branstrom;E. Baizman;M. Sofia
中科院分区：
文献类型：
--
作者：
D. J. Silva;C. Bowe;A. Branstrom;E. Baizman;M. Sofia
合成了在胞壁酸部分含有不同异头基团的细菌脂质I类似物，并在存在和不存在细胞壁膜的情况下在MurG酶测定中进行筛选。在这项研究中获得的结果有助于阐明脂质二磷酸在MurG识别Lipid I中的作用。
Bacterial Lipid I analogues containing different anomeric groups at the muramic acid moiety were synthesized and screened in MurG enzyme assays run in the presence and absence of cell wall membranes. The results obtained in this study help elucidate the role of the lipid diphosphate in the recognition of Lipid I by MurG.