CD69 is independently prognostic in chronic lymphocytic leukemia: a comprehensive clinical and biological profiling study
CD69 is independently prognostic in chronic lymphocytic leukemia: a comprehensive clinical and biological profiling study
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DOI：
10.3324/haematol.2011.052829
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发表时间：
2012-02-01
期刊：
影响因子：
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通讯作者：
Amadori, Sergio
中科院分区：
文献类型：
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作者：
Del Poeta, Giovanni;Del Principe, Maria Ilaria;Amadori, Sergio
背景CD 69在多种造血细胞中表达，是慢性淋巴细胞白血病的早期活化标志物。慢性淋巴细胞白血病是一种临床异质性疾病，需要新的预后参数，可以很容易和有效地管理。设计和方法我们研究了CD 69的流式细胞术在一系列的417例慢性淋巴细胞白血病患者，并比较这与其他生物学和临床指标。结果CD 69与Rai分期β 2-微球蛋白（P = 0.0005）和可溶性CD 23（P
BackgroundCD69 is expressed in several hemopoietic cells and is an early activation marker in chronic lymphocytic leukemia. Chronic lymphocytic leukemia is a clinically heterogeneous disease which needs novel prognostic parameters which can be easily and efficiently managed.Design and MethodsWe investigated CD69 by flow cytometry in a series of 417 patients affected by chronic lymphocytic leukemia and compared this to other biological and clinical prognosticators.ResultsCD69 was associated with Rai stages (P=0.00002), beta(2)-microglobulin (P=0.0005) and soluble CD23 (P