Body weight affects ω-3 polyunsaturated fatty acid (PUFA) accumulation in youth following supplementation in post-hoc analyses of a randomized controlled trial
Body weight affects ω-3 polyunsaturated fatty acid (PUFA) accumulation in youth following supplementation in post-hoc analyses of a randomized controlled trial
复制标题
DOI：
10.1371/journal.pone.0173087
复制
发表时间：
2017-04-05
期刊：
影响因子：
3.7
通讯作者：
Fristad, Mary A.
中科院分区：
文献类型：
--
作者：
Christian, Lisa M.;Young, Andrea S.;Fristad, Mary A.
Omega-3 多不饱和脂肪酸 (PUFA) 的建议摄入量指南在青少年中受到限制，并且主要取决于年龄。然而，不同年龄段的体重差异很大。目前的分析在一项为期 12 周的双盲随机对照试验（2000 毫克 w-3 补充剂或对照胶囊）中检查了 64 名患有情绪障碍的青少年（7-14 岁）的体重和体重指数 (BMI) 对脂肪酸积累的影响。在第一次研究访视时测量体重和身高，并使用首次和研究结束时获得的空腹血样测定 EPA 和 DHA 水平。在补充 w-3 组中，较高的基线体重预测 EPA [B =-0.047，(95% CI =-0.077;-0.017)，omega =-0.54，p = 0.003] 和 DHA [B =-0.02，(95% CI =-0.034；-0.007)，omega =-0.52，p = 0.004]。同样，较高的 BMI 百分位数以及 BMI 类别（体重不足、体重正常、超重/肥胖）预示着 EPA 和 DHA 的积累较少（ps
Guidelines for suggested intake of omega-3 polyunsaturated fatty acids (PUFAs) are limited in youth and rely primarily on age. However, body weight varies considerably within age classifications. The current analyses examined effects of body weight and body mass index (BMI) on fatty acid accumulation in 64 youth (7-14 years) with a diagnosed mood disorder in a double-blind randomized-controlled trial (2000 mg w-3 supplements or a control capsule) across 12 weeks. Weight and height were measured at the first study visit and EPA and DHA levels were determined using fasting blood samples obtained at both the first and end of-study visits. In the w-3 supplementation group, higher baseline body weight predicted less plasma accumulation of both EPA [B =-0.047, (95% CI =-0.077;-0.017), omega =-0.54, p = 0.003] and DHA [B =-0.02, (95% CI =-0.034;-0.007), omega =-0.52, p = 0.004]. Similarly, higher BMI percentile as well as BMI category (underweight, normal weight, overweight/obese) predicted less accumulation of EPA and DHA (ps