Shining the Light on Senescence Associated LncRNAs.
Shining the Light on Senescence Associated LncRNAs.
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揭示衰老相关 LncRNA。
DOI：
10.14336/ad.2016.0810
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发表时间：
2017-04
影响因子：
7.4
通讯作者：
Song X
中科院分区：
文献类型：
--
作者：
Ghanam AR;Xu Q;Ke S;Azhar M;Cheng Q;Song X
细胞衰老可以被描述为一种复杂的应激反应，导致不可逆的细胞周期停滞。这个过程最初被描述为原代细胞在细胞培养过程中经过多次传代后所经历的事件。最近，细胞衰老被认为是一个程序化的过程，当细胞暴露于各种应激时，细胞通过该过程显示衰老表型。细胞衰老与肿瘤抑制和衰老有关，因此衰老可能有助于肿瘤进展和正常组织修复。在这里，我们回顾了不同形式的细胞衰老，以及目前的生物标志物用于识别衰老细胞在体外和体内。此外，我们强调了衰老相关的长非编码RNA（lncRNA）的作用。
Cellular senescence can be described as a complex stress response that leads to irreversible cell cycle arrest. This process was originally described as an event that primary cells go through after many passages of cells during cell culture. More recently, cellular senescence is viewed as a programmed process by which the cell displays a senescence phenotype when exposed to a variety of stresses. Cellular senescence has been implicated in tumor suppression and aging such that senescence may contribute to both tumor progression and normal tissue repair. Here, we review different forms of cellular senescence, as well as current biomarkers used to identify senescent cells in vitro and in vivo. Additionally, we highlight the role of senescence-associated long noncoding RNAs (lncRNAs).