Effect of olfactory manganese exposure on anxiety-related behavior in a mouse model of iron overload hemochromatosis.
Effect of olfactory manganese exposure on anxiety-related behavior in a mouse model of iron overload hemochromatosis.
复制标题
嗅觉锰暴露对铁超载血色素沉着症小鼠模型焦虑相关行为的影响。
DOI：
10.1016/j.etap.2015.06.016
复制
发表时间：
2015
影响因子：
4.3
通讯作者：
Kim,Jonghan
中科院分区：
文献类型：
--
作者：
Ye,Qi;Kim,Jonghan
过量的锰会促进不稳定的情绪行为。我们以前的研究表明，嗅觉锰摄入到大脑中的改变在Hfe −/−小鼠，铁过载血色素沉着症的模型，表明Hfe缺乏可以改变空气中锰的神经毒性。我们确定了反复鼻内滴注MnCl 2 toHfe −/−小鼠后的焦虑相关行为和单胺能蛋白表达。与注入锰的野生型小鼠相比，Hfe−/−小鼠小脑中的锰积累减少，Hfe −/−小鼠也表现出焦虑增加，探索活动减少，纹状体中多巴胺D1受体和去甲肾上腺素转运蛋白升高。此外，铁缺乏减弱锰相关的冲动和修改的酪氨酸羟化酶，囊泡单胺转运蛋白和5-羟色胺转运蛋白的表达锰的影响。总之，我们的数据表明，HFE功能的丧失改变了锰相关的情绪行为，并进一步表明，HFE可能是一个潜在的分子靶点，以减轻锰吸入诱导的情感障碍。
Manganese in excess promotes unstable emotional behavior. Our previous study showed that olfactory manganese uptake into the brain is altered inHfe−/−mice, a model of iron overload hemochromatosis, suggesting that Hfe deficiency could modify the neurotoxicity of airborne manganese. We determined anxiety-related behavior and monoaminergic protein expression after repeated intranasal instillation of MnCl2toHfe−/−mice. Compared with manganese-instilled wild-type mice,Hfe−/−mice showed decreased manganese accumulation in the cerebellum.Hfe−/−mice also exhibited increased anxiety with decreased exploratory activity and elevated dopamine D1 receptor and norepinephrine transporter in the striatum. Moreover, Hfe deficiency attenuated manganese-associated impulsivity and modified the effect of manganese on the expression of tyrosine hydroxylase, vesicular monoamine transporter and serotonin transporter. Together, our data indicate that loss of HFE function alters manganese-associated emotional behavior and further suggest that HFE could be a potential molecular target to alleviate affective disorders induced by manganese inhalation.