Metabolic syndrome emerges after artificial selection for low baroreflex sensitivity
Metabolic syndrome emerges after artificial selection for low baroreflex sensitivity
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DOI：
10.1111/cns.12999
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发表时间：
2018-09-01
影响因子：
5.5
通讯作者：
Liu, Ai-Jun
中科院分区：
文献类型：
--
作者：
Zhang, Li-Li;Zhang, Ying;Liu, Ai-Jun
目的目前尚不清楚受损的BRS是否在心血管疾病的发生中发挥关键作用。BRS受损的分子机制仍有待充分阐明。我们假设，选择大鼠的基础上缺乏和正常的内在BRS将产生模型，反映心血管疾病的risk.Methods和ResultsTwenty代的选择产生动脉压力反射低大鼠和正常大鼠，不同的BRS约2.5倍的变化。ABR-DRs出现代谢综合征（包括高血压、超重、高血糖和高血糖），虽然ABR-DRs进食较少，但体重增加明显。恢复受损的BRS可能是代谢综合征治疗干预的有效靶点。
AimsIt is unclear whether the impaired BRS plays a key role in the incidence of cardiovascular diseases. The molecular mechanism of impaired BRS remains to be fully elucidated. We hypothesized that selection of rats based on deficient and normal intrinsic BRS would yield models that reflect cardiovascular diseases risk.Methods and ResultsTwenty generations of selection produced arterial baroreflex low rats and normal rats that differed in BRS by about 2.5-fold change. Metabolic syndrome (including hypertension, overweight, hyperlipemia, and hyperglycemia) emerged in ABR-DRs. Although ABR-DRs consumed less food, they gained significantly more body weight.ConclusionOur study demonstrated that intrinsic low BRS induced hypertension and metabolic disorder. Restoration of impaired BRS might be a potent target of therapeutic intervention in metabolic syndrome.