The role of xanthine dioxygenase in the biosynthetic pathway of 2-aza-8-oxohypoxanthine of Lepista sordida
The role of xanthine dioxygenase in the biosynthetic pathway of 2-aza-8-oxohypoxanthine of Lepista sordida
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黄嘌呤双加氧酶在 Lepista sordida 2-aza-8-oxohypoxanthine 生物合成途径中的作用
DOI：
10.1093/bbb/zbad005
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
H.
中科院分区：
文献类型：
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作者：
Kotajima;M.;Choi;J.-H.;Suzuki;T.;Wu;J.;Hirai;H.;Nelson;D. C.;Ouchi;H.;Inai;M.;Dohra;H.;Kawagishi;H.
2-氮杂次黄嘌呤 (AHX) 和 2-氮杂-8-氧代黄嘌呤 (AOH) 被发现是仙女环的致病物质，已知它们是形成仙女环的 Lepista sordida 中内源的。在这项研究中，我们发现黄嘌呤双加氧酶（一种 α-酮戊二酸依赖性双加氧酶）可能会催化真菌中 AHX 转化为 AOH。此外，该酶是第一个报道的次黄嘌呤代谢的不依赖于钼蝶呤的蛋白质。
2-Azahypoxanthine (AHX) and 2-aza-8-oxohypoxanthine (AOH), discovered as causal substances of fairy rings are known to be endogenous in the fairy ring-formingLepista sordida. In this study, we showed that xanthine dioxygenase, an a-ketoglutarate-dependent dioxygenase, might catalyze the conversion of AHX to AOH in the fungus. Furthermore, this enzyme is the first reported molybdopterin-independent protein of hypoxanthine metabolism.