A possible role for imprinted genes in inbreeding avoidance and dispersal from the natal area in mice.
A possible role for imprinted genes in inbreeding avoidance and dispersal from the natal area in mice.
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印记基因在小鼠近亲繁殖避免和从出生区域扩散中的可能作用。
DOI：
10.1098/rspb.2001.1911
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Allen,NicholasD
中科院分区：
文献类型：
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作者：
Isles,AnthonyR;Baum,MichaelJ;Ma,Dan;Szeto,Abigail;Keverne,EricB;Allen,NicholasD
哺乳动物基因子集的表达受到亲本起源效应（POE）的影响，其中大部分可以通过基因组印记来解释。对突变动物的分析表明，许多印记基因影响大脑发育和行为。在这里，我们为POE提供了嗅觉相关行为和对母亲气味线索的敏感性的证据。这是通过观察胚胎移植到基因无关的养父母的互惠杂交f1小鼠的气味偏好行为来研究的。我们确定成年雄性和雌性都表现出对母系遗传而非父系起源的女性尿液气味的回避。研究发现，这不是由于以前接触过这些气味，也不是由于自我学习，而是可能与嗅觉系统的直接影响有关，因为互惠的雄性对雌性气味线索表现出不同的敏感性。目前解释印记进化最有力的理论是冲突假说，该假说关注的是母体资源分配给发育中的胎儿。亲属关系的考虑在印迹基因的选择中也可能很重要，我们在此背景下讨论了我们的发现，表明印迹基因直接作用于嗅觉系统，促进断奶后从出生区域扩散。
The expression of a subset of mammalian genes is subject to parent of origin effects (POE), most of which can be explained by genomic imprinting. Analysis of mutant animals has demonstrated that a number of imprinted genes influence brain development and behaviour. Here we provide evidence for POE on olfactory related behaviour and sensitivity to maternal odour cues. This was investigated by examining the odour preference behaviour of reciprocal cross F1mice made by embryo transfer to genetically unrelated foster parents. We determined that both adult males and females show an avoidance of female urinary odours of their genetic maternal but not paternal origin. This was found not to be due to any previous exposure to these odours or due to self‐learning, but may be related to direct effects on the olfactory system, as reciprocal F1males show differential sensitivity to female odour cues. Currently the most robust theory to explain the evolution of imprinting is the conflict hypothesis that focuses on maternal resource allocation to the developing foetus. Kinship considerations are also likely to be important in the selection of imprinted genes and we discuss our findings within this context, suggesting that imprinted genes act directly on the olfactory system to promote post‐weaning dispersal from the natal area.