Specification of DNA binding activity of NF-kappaB proteins.
Specification of DNA binding activity of NF-kappaB proteins.
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DOI：
10.1101/cshperspect.a000067
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发表时间：
2009-10
影响因子：
7.2
通讯作者：
F. Wan;M. Lenardo
中科院分区：
文献类型：
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作者：
F. Wan;M. Lenardo
核因子-kappaB(NF-kappaB)是一种可诱导的、特异的基因调控的多效性介质，涉及免疫反应、炎症、细胞增殖和死亡等多种生物学活动。对核因子-kappaB DNA结合活性的微调是其作为转录因子的基本功能所必需的。越来越多的文献表明，这一过程可以通过不同的蛋白质亚群在多个水平上进行优雅和特定的控制。特别是，最近发现的核因子-kappaB的一个非REL亚基本身为理解核因子-kappaB的选择性高亲和力DNA结合特异性提供了新的途径，这种特异性是由整个复合体内的协同作用所赋予的。在这里，我们回顾了核因子-kappaB复合体DNA结合活性的指定机制，这是核因子-kappaB转录调控的最重要的方面之一。
Nuclear factor-kappaB (NF-kappaB) is a pleiotropic mediator of inducible and specific gene regulation involving diverse biological activities including immune response, inflammation, cell proliferation, and death. The fine-tuning of the NF-kappaB DNA binding activity is essential for its fundamental function as a transcription factor. An increasing body of literature illustrates that this process can be elegantly and specifically controlled at multiple levels by different protein subsets. In particular, the recent identification of a non-Rel subunit of NF-kappaB itself provides a new way to understand the selective high-affinity DNA binding specificity of NF-kappaB conferred by a synergistic interaction within the whole complex. Here, we review the mechanism of the specification of DNA binding activity of NF-kappaB complexes, one of the most important aspects of NF-kappaB transcriptional control.