Effect of peritoneal dialysis versus hemodialysis on renal anemia in renal in end-stage disease patients: a meta-analysis.
Effect of peritoneal dialysis versus hemodialysis on renal anemia in renal in end-stage disease patients: a meta-analysis.
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DOI：
10.1080/0886022x.2016.1244079
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发表时间：
2017-11
期刊：
影响因子：
3
通讯作者：
Xu ZG
中科院分区：
文献类型：
--
作者：
Wang WN;Zhang WL;Sun T;Ma FZ;Su S;Xu ZG
本荟萃分析旨在评价腹膜透析(PD)和血液透析(HD)对肾病患者肾性贫血(RA)的影响。检索2015年6月前发表的相关研究。以血红蛋白、铁蛋白、转铁蛋白饱和度指数、血清白蛋白、甲状旁腺激素5项指标为指标，用合并优势比(OR)95%可信区间(CI)评价HD和PD对RA的影响。通过敏感度分析和发表偏倚评估来评价研究结果的稳定性和可靠性。本次Meta分析共纳入14项符合条件的研究，其中HD组1103例，PD组625例。HD组和PD组的血红蛋白(SMD = −0.2 3，95%CI：−0.74~0.2 8)、铁蛋白(SMD = 0.0 1，95%CI：−0.5 9~0.6 2)、甲状旁腺激素(SMD = 0.11，95%CI：−1.5 3~1.75)和转铁蛋白饱和指数(SMD = −0.0 6，95%CI：−0.67~0.5 6)差异无统计学意义。HD组血清白蛋白含量明显高于PD组( = 1.5 8，95%CI：0.35~2.81)。纳入的两项研究都不能逆转汇集的副作用，埃格的测试也没有显示出发表偏倚。这两种透析策略对肾病患者的类风湿性关节炎有相似的效果。
The aim of this meta-analysis was to evaluate the effect of peritoneal dialysis (PD) and hemodialysis (HD) on renal anemia (RA) in renal disease patients by a meta-analysis. Relevant studies published before June 2015 were searched. Pooled odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the effect of HD and PD on RA based on five indexes: hemoglobin, ferritin, transferrin saturation index, serum albumin, and parathyroid hormone. Sensitivity analysis and publication bias assessment were conducted to evaluate the stability and reliability of our results. A total of fourteen eligible studies with 1103 cases underwent HD and 625 cases underwent PD were used for this meta-analysis. There were no significant difference for levels of hemoglobin (SMD = −0.23, 95% CI: −0.74 to 0.28), ferritin (SMD = 0.01, 95% CI: −0.59 to 0.62), parathyroid hormone (SMD = 0.11, 95% CI: −1.53 to 1.75) and transferrin saturation index (SMD = −0.06, 95% CI: −0.67 to 0.56) between HD and PD group. However, the content of serum albumin in HD group was much more than that in PD group (SMD = 1.58, 95% CI: 0.35 to 2.81). Neither of the included studies could reverse the pooled side effect and Egger’s test demonstrated no publication bias. Both of the two dialysis strategies have a similar effect on RA in renal disease patients.