Laboratory animal allergy: a clinical survey of an exposed population.
Laboratory animal allergy: a clinical survey of an exposed population.
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实验动物过敏：对暴露人群的临床调查。
DOI：
10.1136/oem.38.1.38
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
R. N. Hill
中科院分区：
文献类型：
--
作者：
A. Slovak;R. N. Hill
为了解实验动物变态反应（LAA）症状的发生率和严重程度，对某制药公司从事实验动物工作的人员进行了临床调查。该疾病的总患病率为30%，发现了两种可区分的LAA综合征，称为局部LAA和进行性LAA。第二种是鼻炎逐渐导致哮喘，点刺试验阳性。点刺试验仅对后者有诊断价值。过敏性鼻炎并不具有发生LAA的特殊风险，但如果他们这样做，则更有可能进展为哮喘。对选择和管理政策的影响进行了概述，并提出了进一步研究LAA的具体措施。
A clinical survey of workers exposed to laboratory animals in a pharmaceutical company was designed to discover the prevalence and severity of symptoms of laboratory animal allergy (LAA). The overall prevalence of the condition was 30%, and two distinguishable LAA syndromes, termed regional and progressive LAA, were found. The first is characterised by rhinitis with negative skin prick tests. The second consists of rhinitis leading progressively to asthma with positive prick tests. Prick tests were useful diagnostically only in the latter. Atopes were shown not to be at special risk of developing LAA, but if they did so were more likely to progress to asthma. The implications for selection and management policy are outlined and specific measures for the further study of LAA are proposed.