Fluor-hydroxyapatite sol-gel coating on titanium substrate for hard tissue implants
Fluor-hydroxyapatite sol-gel coating on titanium substrate for hard tissue implants
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DOI：
10.1016/j.biomaterials.2003.09.104
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发表时间：
2004-08-01
期刊：
影响因子：
14
通讯作者：
Knowles, JC
中科院分区：
文献类型：
--
作者：
Kim, HW;Kim, HE;Knowles, JC
采用溶胶-凝胶法在钛基体上制备了羟基磷灰石（HA）和氟羟基磷灰石（FHA）薄膜。在溶胶制备过程中，不同浓度的F-被掺入磷灰石结构中。在浸渍和随后的500 ℃热处理后，所有涂层都获得了典型的磷灰石结构。所获得的膜是均匀和致密的，具有类似于5 μ m的厚度。涂层的溶解速率随着磷灰石结构内F-掺入的增加而降低，这证明了通过HA和FHA的功能梯度涂层定制溶解度的可能性。随着F-掺入量的增加，包被层上的细胞增殖率略有下降.与纯Ti相比，所有HA和FHA包被样品上细胞的碱性磷酸酶（ALP）活性显示出高得多的表达水平。这证实了用溶胶-凝胶涂覆处理的基底上的细胞功能活性的改善。(C)2003爱思唯尔有限公司。保留所有权利。
Hydroxyapatite (HA) and fluor-hydroxyapatite (FHA) films were deposited on a titanium substrate using a sol-gel technique. Different concentrations of F- were incorporated into the apatite structure during the sol preparation. Typical apatite structures were obtained for all coatings after dipping and subsequent heat treatment at 500 degreesC. The films obtained were uniform and dense, with a thickness of similar to 5 mum. The dissolution rate of the coating layer decreased with increasing F- incorporation within the apatite structure, which demonstrates the possibility of tailoring the solubility by a functional gradient coating of HA and FHA. The cell proliferation rate on the coating layer decreased slightly with increasing F- incorporation. The alkaline phosphatase (ALP) activity of the cells on all the HA and FHA coated samples showed much higher expression levels compared to pure Ti. This confirmed the improved activity of cell functions on the substrates with the sol-gel coating treatment. (C) 2003 Elsevier Ltd. All rights reserved.