Activation-induced cell death in T cells and autoimmunity.
Activation-induced cell death in T cells and autoimmunity.
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DOI：
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发表时间：
2004-06
影响因子：
24.1
通讯作者：
Jian Zhang;Xuemei Xu;Yong Liu
中科院分区：
文献类型：
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作者：
Jian Zhang;Xuemei Xu;Yong Liu
激活诱导的细胞死亡(AICD)是Fas和Fas配体相互作用的结果，负责维持对自身抗原的耐受。AICD的缺陷可能导致自身免疫的发展。在过去的几年里，对AICD的机制(S)及其在自身免疫性疾病发病机制中的潜在作用的理解已经取得了很大的进展。本文就T细胞对AICD易感性的调控及其可能参与自身免疫性疾病的研究进展作一综述。
Activation-induced cell death (AICD), which results from the interaction between Fas and Fas ligand, is responsible for maintaining tolerance to self-antigen. A defect in AICD may lead to development of autoimmunity. During the last several years, much progress has been made in understanding the mechanism(s) of AICD and its potential role in the pathogenesis of autoimmune diseases. In this review, we summarize the most recent progress on the regulation of the susceptibility of T cells to AICD and its possible involvement in autoimmune diseases.