Breast Lesions: Quantitative Elastography with Supersonic Shear Imaging-Preliminary Results

Breast Lesions: Quantitative Elastography with Supersonic Shear Imaging-Preliminary Results
复制标题

DOI：
10.1148/radiol.10090385
复制
发表时间：
2010-07-01
期刊：
RADIOLOGY
影响因子：
19.7
通讯作者：
Neuenschwander, Sylvia
Neuenschwander, Sylvia
中科院分区：
医学1区
文献类型：
--
作者：
Athanasiou, Alexandra;Tardivon, Anne;Neuenschwander, Sylvia

文献摘要

被引文献

相似文献

目的：应用超声剪切成像技术(SSI)确定乳腺病变在超声弹性成像(US)中的表现，并评价病变硬度的量化值与病理结果的相关性，作为参考标准。材料和方法：本研究由法国生物医学研究项目患者保护国家委员会批准。所有患者均提供书面知情同意书。对46例女性(平均年龄57.6岁，年龄38~71岁)的48个乳腺病变(良性28个，恶性20个，平均大小14.7 mm)进行常规超声和SSI定量弹性成像检查，所有病例均有病理结果。定量损伤弹性用杨氏模数(千帕斯卡)来测量。通过使用接收器操作特征曲线分析来评估诊断性能，获得灵敏度、特异度和曲线下面积。结果：所有乳腺病变均在SSI上被检出。恶性病变的平均弹性值为146.6 kPa+/-40.05(标准差)，而良性病变的平均弹性值为45.3kpa+/-41.1(P&lt；.001)。结论：SSI提供了定量的弹性测量，从而增加了补充信息，可能有助于B超对乳腺病变的定性。
Purpose: To determine the appearance of breast lesions at quantitative ultrasonographic (US) elastography by using supersonic shear imaging (SSI) and to assess the correlation between quantitative values of lesion stiffness and pathologic results, which were used as the reference standard.Materials and Methods: This study was approved by the French National Committee for the Protection of Patients Participating in Biomedical Research Programs. All patients provided written informed consent. Conventional US and SSI quantitative elastography were performed in 46 women (mean age, 57.6 years; age range, 38-71 years) with 48 breast lesions (28 benign, 20 malignant; mean size, 14.7 mm); pathologic results were available in all cases. Quantitative lesion elasticity was measured in terms of the Young modulus (in kilopascals). Sensitivity, specificity, and area under the curve were obtained by using a receiver operating characteristic curve analysis to assess diagnostic performance.Results: All breast lesions were detected at SSI. Malignant lesions exhibited a mean elasticity value of 146.6 kPa +/- 40.05 (standard deviation), whereas benign ones had an elasticity value of 45.3 kPa +/- 41.1 (P < .001). Complicated cysts were differentiated from solid lesions because they had elasticity values of 0 kPa (no signal was retrieved from liquid areas).Conclusion: SSI provides quantitative elasticity measurements, thus adding complementary information that potentially could help in breast lesion characterization with B-mode US.