Self-reported diabetes and mortality in a prospective Chinese elderly cohort Study in Hong Kong
Self-reported diabetes and mortality in a prospective Chinese elderly cohort Study in Hong Kong
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DOI：
10.1016/j.ypmed.2014.03.021
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发表时间：
2014-07-01
影响因子：
5.1
通讯作者：
Lam, Tai Hing
中科院分区：
文献类型：
--
作者：
Shen, Chen;Schooling, C. Mary;Lam, Tai Hing
目的：在西方国家，糖尿病与包括癌症、心血管疾病和呼吸系统疾病在内的所有原因和特定原因的死亡呈正相关。在疾病模式不同的中国人中，糖尿病的发病率较高，且缺血性心脏病(IHD)的发病率较低，糖尿病与IHD呈正相关。方法：对1998年7月至2001年12月在香港政府卫生署老年健康中心登记的66,820名中国人(65岁以上)的人群前瞻性队列进行多变量Cox回归分析，直至2012年5月31日。结果：在10.9年的随访期内，19,845人死亡。调整了年龄、性别、社会经济地位、饮酒、吸烟等因素后，自我报告的糖尿病与全因死亡相关(危险比(HR)=1.56，95%可信区间(CI)1.51，1.62)、心血管疾病(HR=1.84，95%C11.72，1.96)、癌症(HR=1.11，95%CI 1.03至1.20)、肝癌(HR=1.38，95%CI 1.13至1.69)和胃癌(HR=1.38，95%CI 1.03至1.85)。运动和体重指数。结论：这种关联模式表明，在这个和类似的人群中，需要进一步研究糖尿病的驱动因素。(C)2014 Elsevier Inc.保留所有权利。
Objective: In Western countries, diabetes mellitus is positively associated with death from all- and specific-causes including cancer, cardiovascular and respiratory diseases. In a Chinese setting with a different disease pattern: high diabetes rates in a relatively non-obese population with low ischemic heart disease (IHD) rates where diabetes is positively associated with IHD, we examined the association of self-reported diabetes with death among older people.Methods: Multivariable Cox regression analysis was used in a population-based prospective cohort of 66,820 Chinese (65 + years) enrolled from July 1998 to December 2001 at Elderly Health Centers of the Hong Kong Government Department of Health, followed until May 31, 2012.Results: During 10.9 years of follow-up, 19,845 deaths occurred. Self-reported diabetes was associated with death from all-causes (hazard ratio (HR) = 1.56,95% confidence interval (CI) 1.51, 1.62), cardiovascular disease (HR = 1.84,95% C11.72, 1.96), cancer (HR = 1.11,95% Cl 1.03 to 1.20), liver cancer (HR = 1.38, 95% Cl 1.13 to 1.69) and stomach cancer (HR = 1.38,95% Cl 1.03 to 1.85), adjusted for age, sex, socio-economic position, alcohol use, smoking, exercise and body mass index.Conclusion: Such a pattern of associations suggests that further investigation into the drivers of diabetes is required in this and similar populations. (C) 2014 Elsevier Inc All rights reserved.