The novel estrogen receptor-beta subtype: Potential role in the cell- and promoter-specific actions of estrogens and anti-estrogens
The novel estrogen receptor-beta subtype: Potential role in the cell- and promoter-specific actions of estrogens and anti-estrogens
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DOI：
10.1016/s0014-5793(97)00413-4
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发表时间：
1997-06-23
期刊：
影响因子：
3.5
通讯作者：
Gustafsson, JA
中科院分区：
文献类型：
--
作者：
Kuiper, GGJM;Gustafsson, JA
最近发现，一个额外的雌激素受体（ER）亚型存在于各种大鼠，小鼠和人类组织中，推进了我们对雌激素信号转导机制的理解。第二种雌激素受体亚型（ER β）的发现表明存在两种以前未被认识的雌激素信号传导途径：通过在仅表达该亚型的组织中的ER β亚型，以及通过在表达两种ER亚型的组织中形成异源二聚体。已经提出了各种模型来解释雌激素和抗雌激素的细胞和启动子特异性效应，所有这些都是基于只有一个ER基因存在的假设。这篇小综述描述了其中的几种模型，并重点介绍了新的ER β亚型在这方面可能发挥的潜在作用。(C)1997年欧洲生物化学学会联合会。
The recent discovery that an additional estrogen receptor (ER) subtype is present in various rat, mouse and human tissues has advanced our understanding of the mechanisms underlying estrogen signalling. The discovery of a second ER subtype (ER beta) suggests the existence of two previously unrecognised pathways of estrogen signalling: via the ER beta subtype in tissues exclusively expressing this subtype and via the formation of heterodimers in tissues expressing both ER subtypes. Various models have been suggested as explanations for the striking cell- and promoter-specific effects of estrogens and anti-estrogens, all on the basis of the assumption that only a single ER gene exists. This minireview describes several of these models and focuses on the potential role which the novel ER beta subtype might have in this regard. (C) 1997 Federation of European Biochemical Societies.