The Anaphase Promoting Complex/Cyclosome (APC/C): A Versatile E3 Ubiquitin Ligase
The Anaphase Promoting Complex/Cyclosome (APC/C): A Versatile E3 Ubiquitin Ligase
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DOI：
10.1007/978-3-030-28151-9_18
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发表时间：
2019-01-01
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影响因子：
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通讯作者：
Bolanos-Garcia, Victor M.
中科院分区：
文献类型：
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作者：
Curtis, Natalie L.;Bolanos-Garcia, Victor M.
在本章中，我们讨论了人类E3泛素连接酶后期促进复合物/环小体（APC/C）在有丝分裂中的重要作用，以及APC/C在细胞分裂控制之外的细胞过程中的重要作用的新证据，如基因组完整性的调节和神经系统的细胞分化。我们考虑APC/C失调在神经系统疾病阿尔茨海默病（AD）的病理生理中的潜在早期作用。我们还讨论了某些脱氧核糖核酸（DNA）和核糖核酸（RNA）病毒如何通过利用APC/C泛素连接酶活性来控制宿主的细胞分裂调节系统，并假设了病毒操纵APC/C的合理分子机制。我们还研究了这种多亚基蛋白组装的功能缺陷如何驱动异常细胞增殖，并最终论证了APC/C作为治疗慢性恶性肿瘤（如癌症）的创新疗法开发的有希望的治疗靶点的潜力。
In the present chapter we discuss the essential roles of the human E3 ubiquitin ligase Anaphase Promoting Complex/Cyclosome (APC/C) in mitosis as well as the emerging evidence of important APC/C roles in cellular processes beyond cell division control such as regulation of genomic integrity and cell differentiation of the nervous system. We consider the potential incipient role of APC/C dysregulation in the pathophysiology of the neurological disorder Alzheimer's disease (AD). We also discuss how certain Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) viruses take control of the host's cell division regulatory system through harnessing APC/C ubiquitin ligase activity and hypothesise the plausible molecular mechanisms underpinning virus manipulation of the APC/C. We also examine how defects in the function of this multisubunit protein assembly drive abnormal cell proliferation and lastly argue the potential of APC/C as a promising therapeutic target for the development of innovative therapies for the treatment of chronic malignancies such as cancer.