Pharmacokinetic and pharmacodynamic modelling of the novel human granulocyte colony‐stimulating factor derivative Maxy‐G34 and pegfilgrastim in rats
Pharmacokinetic and pharmacodynamic modelling of the novel human granulocyte colony‐stimulating factor derivative Maxy‐G34 and pegfilgrastim in rats
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DOI：
10.1111/j.1365-2184.2009.00641.x
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发表时间：
2009-12
影响因子：
8.5
通讯作者：
Markus Scholz;Christoph Engel;D. Apt;S. L. Sankar;E. Goldstein;Markus Loeffler
中科院分区：
文献类型：
--
作者：
Markus Scholz;Christoph Engel;D. Apt;S. L. Sankar;E. Goldstein;Markus Loeffler
目的：本研究旨在比较聚乙二醇非格司亭（一种药物重组人粒细胞集落刺激因子（rhG-CSF））与新开发的试剂 Maxy-G34 的药代动力学和药效学。该比较是使用大鼠实验和粒细胞生成的生物数学模型进行的。
Objectives: This study aims to compare pharmacokinetics and pharmacodynamics of pegfilgrastim, a pharmaceutical recombinant human granulocyte colony‐stimulating factor (rhG‐CSF), with that of a newly developed reagent, Maxy‐G34. This comparison was performed using rat experiments and biomathematical modelling of granulopoiesis.