Extent of Visceral Pleural Invasion Affects Prognosis of Resected Non-small Cell Lung Cancer: A meta-analysis.
Extent of Visceral Pleural Invasion Affects Prognosis of Resected Non-small Cell Lung Cancer: A meta-analysis.
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内脏胸膜浸润程度影响切除的非小细胞肺癌的预后：一项荟萃分析
DOI：
10.1038/s41598-017-01845-7
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发表时间：
2017-05-08
影响因子：
4.6
通讯作者：
Zhou Q
中科院分区：
文献类型：
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作者：
Wang T;Zhou C;Zhou Q
内脏胸膜侵犯(VPI)已被认为是非小细胞肺癌(NSCLC)的不良预后因素。然而，VPI范围(PL0、PL1和PL2)的预后意义仍存在争议。我们进行了一项元分析，以总结关于这一主题的现有证据。检索PubMed、EMBASE、Ovid和Cochrane图书馆从最初到2016年5月9日的已发表研究。共有16项研究纳入Meta分析。结果显示，PL1或PL2患者的总体生存率低于PL0患者(HR = 为1.555，95%CI为1.399，1.730；HR = 为2.447，95%CI为1.913，3.130)，而PL2患者的总体生存率甚至低于PL1患者(HR = 为1.287，95%CI为1.114，1.487)。PL1和PL2患者的5年生存率低于PL0患者(OR = 0.515，95%CI 0.415，0.640；OR = 0.441，95%CI 0.336，0.579)，PL2患者的5年生存率甚至低于PL1患者(OR = 0.706，95%CI 0.545，0.915)。综上所述，VPI对NSCLC术后预后的影响程度，在临床实践和临床试验中应分为PL1和PL2两种类型。
Visceral pleural invasion (VPI) has been known to be an adverse prognostic factor in non-small cell lung cancer (NSCLC). However, the prognostic significance of extent of VPI (PL0, PL1 and PL2) remains controversial. We conduct a meta-analysis to summarize available evidence on this topic. PubMed, EMBASE, OVID and The Cochrane Library were searched for published studies from inception to May 9, 2016. A total of 16 studies were included in meta-analysis. Our results showed that patients with PL1 or PL2 had poorer overall survival compared with PL0 (HR = 1.555, 95% CI 1.399, 1.730; HR = 2.447, 95% CI 1.913, 3.130) and patients with PL2 had even poorer overall survival than PL1 (HR = 1.287, 95% CI 1.114, 1.487). Patients with PL1 or PL2 had lower 5-year survival rate than PL0 patients (OR = 0.515, 95% CI 0.415, 0.640; OR = 0.441, 95% CI 0.336, 0.579) and patients with PL2 had even lower 5-year survival rate than PL1 (OR = 0.706, 95% CI 0.545, 0.915). In conclusion, extent of VPI impacts the prognosis of resected NSCLC and VPI should be categorized as PL1 and PL2 in the terms of clinical practice and trials.
DOI：
10.3779/j.issn.1009-3419.2010.03.04
发表时间：
2010-03
期刊：
Zhongguo fei ai za zhi = Chinese journal of lung cancer
影响因子：
--
作者：
Hu Z;Shen-Tu Y;Ding Z;Tan Q;Zhou Y
通讯作者：
Zhou Y