The epigenetic role of vitamin C in health and disease.
The epigenetic role of vitamin C in health and disease.
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维生素C在健康和疾病中的表观遗传作用。
DOI：
10.1007/s00018-016-2145-x
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Wang G
中科院分区：
文献类型：
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作者：
Camarena V;Wang G
最近的进展揭示了维生素 C 在表观遗传调控中以前未知的功能。在生理 pH 条件下，维生素 C 主要以抗坏血酸阴离子形式存在。抗坏血酸被发现是负责 DNA 去甲基化的甲基胞嘧啶双加氧酶的辅助因子，并且也可能是一些催化组蛋白去甲基化的包含 JmjC 结构域的组蛋白去甲基化酶的辅助因子。因此，抗坏血酸生物利用度的变化会影响 DNA 和组蛋白的去甲基化，进一步导致不同的表型表现。抗坏血酸缺乏可以在发育和衰老的不同阶段的不同组织中系统地、空间地和时间地呈现。在这里，我们回顾了抗坏血酸缺乏如何可能参与胚胎和产后发育，并通过表观遗传失调在神经退行性疾病和癌症等各种疾病中发挥作用。
Recent advances have uncovered a previously unknown function of vitamin C in epigenetic regulation. Vitamin C exists predominantly as an ascorbate anion under physiological pH conditions. Ascorbate was discovered as a cofactor for methylcytosine dioxygenases that are responsible for DNA demethylation, and also as a likely cofactor for some JmjC domain-containing histone demethylases that catalyze histone demethylation. Variation in ascorbate bioavailability thus can influence the demethylation of both DNA and histone, further leading to different phenotypic presentations. Ascorbate deficiency can be presented systematically, spatially and temporally in different tissues at the different stages of development and aging. Here, we review how ascorbate deficiency could potentially be involved in embryonic and postnatal development, and plays a role in various diseases such as neurodegeneration and cancer through epigenetic dysregulation.