Activation of the receptor protein tyrosine kinase EphB4 in endometrial hyperplasia and endometrial carcinoma
Activation of the receptor protein tyrosine kinase EphB4 in endometrial hyperplasia and endometrial carcinoma
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DOI：
10.1093/annonc/mdg072
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发表时间：
2003-02-01
影响因子：
50.5
通讯作者：
Andres, AC
中科院分区：
文献类型：
--
作者：
Berclaz, G;Karamitopoulou, E;Andres, AC
背景资料：酪氨酸激酶Eph家族的成员与胚胎形态形成和血管发育有关，然而，对它们在成年生物体中的作用知之甚少。我们已经观察到雌激素依赖性EphB 4在正常乳腺中的表达，表明其在该器官的乳腺癌控制的稳态中的意义。由于子宫内膜是类似的激素依赖性器官，并且子宫内膜癌被认为是由雌激素刺激引起的，因此我们研究了EphB 4在正常人子宫内膜和其癌变过程中的表达。采用免疫组化方法检测26例正常子宫内膜组织中EphB 4的表达，结果：EphB 4蛋白在正常子宫内膜组织中不表达，在子宫内膜增生症组织中EphB 4蛋白表达阳性率为15%，在子宫内膜样腺癌组织中EphB 4蛋白表达阳性率为102%，EphB 4蛋白表达与子宫内膜癌的临床及预后有关。令人惊讶的是，我们观察到急剧增加（P
Background: Members of the Eph family of tyrosine kinases have been implicated in embryonic pattern formation and vascular development; however, little is known about their role in the adult organism. We have observed estrogen-dependent EphB4 expression in the normal breast suggesting its implication in the hormone-controlled homeostasis of this organ. Since the endometrium is a similarly hormone dependent organ and endometrial carcinoma is thought to result from estrogenic stimulation, we have investigated EphB4 expression in normal human endometrium and during its carcinogenesis.Patients and methods: EphB4 expression was analyzed immunohistochemically in 26 normal endometrium specimens, 15 hyperplasias and 102 endometrioid adenocarcinomas and correlated with clinical and prognostic tumor characteristics.Results: In normal endometrial tissue no EphB4 protein was detected. Strikingly, we observed a drastic increase (P