Effect of hyperthyroidism and hypothyroidism on the metabolism of testosterone and androstenedione in man.
Effect of hyperthyroidism and hypothyroidism on the metabolism of testosterone and androstenedione in man.
复制标题
甲状腺功能亢进症和甲状腺功能减退症对男性睾酮和雄烯二酮代谢的影响。
DOI：
10.1210/jcem-29-2-164
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发表时间：
1969
期刊：
影响因子：
--
通讯作者：
J. Olivo
中科院分区：
文献类型：
--
作者：
G. Gordon;A. Southren;S. Tochimoto;J. Rand;J. Olivo
本文研究了甲亢和甲减患者的血浆睾酮浓度、代谢清除率(MCRT)和血浆生成率，雄烯二酮(MCRA)的代谢清除率，以及这些类固醇的转化率和速率转移常数。甲亢患者的MCRT和睾酮/雄烯二酮转化率均显着降低。这些变化与两性血浆中睾酮水平的升高有关，从而导致雄激素的血浆生成率正常。甲亢患者的MCRA和MCRA/m2与正常组无显著差异。然而，在这种疾病中，雄烯二酮到睾酮的转化率显著增加。睾酮和雄烯二酮的速率转移常数与正常相比没有变化。在恢复正常甲状腺状态后，这些值又恢复到正常。甲减与MCRT、MCRT/m2和素转换率升高有关。
ABSTRACT The plasma concentration, metabolic clearance (MCRT) and plasma production rates of testosterone, the metabolic clearance rates of androstenedione (MCRA), the conversion ratios and rate transfer constants of these steroids were studied in hyperthyroidism and hypothyroidism. In hyperthyroidism there occurred a significant decrease in both the MCRT and conversion ratio of testosterone to androstenedione. These changes were associated with an increased plasma level of testosterone in both sexes resulting in a normal plasma production rate of the androgen. The MCRA and MCRA/m2 in hyperthyroidism was not significantly different from normal. However, the conversion ratio of androstenedione to testosterone was significantly increased in this disorder. The rate transfer constants of testosterone and androstenedione were unchanged from normal. Following return to the euthyroid state the values returned to normal. Hypothyroidism was associated with an increased MCRT, MCRT/m2 and conversion ratio of testost...