An update on regional brain volume differences associated with mood disorders
An update on regional brain volume differences associated with mood disorders
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DOI：
10.1097/01.yco.0000194371.47685.f2
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发表时间：
2006-01-01
影响因子：
6.9
通讯作者：
MacQueen, G
中科院分区：
文献类型：
--
作者：
Campbell, S;MacQueen, G
综述目的在一些针对情绪障碍患者的磁共振成像研究中，大脑结构发生了明显的变化，但结果并不一致。本次综述的重点是检查情绪障碍患者的人口统计学或临床特征是否与区域脑容量变化相关。在 MEDLINE 上对 2004 年 1 月至 2005 年 7 月期间的英文文献进行了系统检索。对所有报告中引用的参考文献进行了反复搜索，以找出缺失的研究。 最新发现 最近的研究重点关注可能有助于调和重度抑郁症和双相情感障碍区域脑容量变化的不同报告的因素。在患有复发性重度抑郁症的患者中，海马体积较小是明显的，但在成人抑郁症病程的早期通常没有报道。在儿童期发病的患者中，海马体积较小可能很明显。双相情感障碍中海马体积较小的情况很少见，但迄今为止的研究尚未解释疾病史或治疗状态。重度抑郁症或双相情感障碍患者杏仁核体积变化的报道不一致。其他大脑区域的报道相对较少，包括额叶皮层和纹状体区域。大量临床前文献表明，各种精神药物可能具有神经营养和神经保护作用，因此记录治疗史至关重要。总结患者的年龄、性别、发病年龄、病程和治疗状态可能会影响情绪障碍患者区域脑容量变化的检测。
Purpose of review Structural brain changes are apparent in some magnetic resonance imaging studies of patients with mood disorders, but results are inconsistent. The focus of this review is to examine whether there are demographic or clinical characteristics of people with mood disorders that are associated with regional brain volume changes. A systematic search of the literature in English, from January 2004 to July 2005, was performed on MEDLINE. References cited in all reports were searched iteratively to identify missing studies.Recent findings Recent studies have focused on factors that might help to reconcile the divergent reports of regional brain volume changes in major depressive disorder and bipolar disorder. Small hippocampal volumes are apparent in patients with recurrent major depressive disorder, but not generally reported early in the course of adult onset depression. Small hippocampal volumes may be apparent in patients with childhood onset illness. Small hippocampal volumes are infrequently reported in bipolar disorder, but studies to date have not accounted for illness history or treatment status. Changes in amygdala volumes are inconsistently reported in patients with major depressive disorder or bipolar disorder. There are relatively fewer reports of other brain regions, including the areas of the frontal cortex and striatum. An extensive preclinical literature suggests that various psychotropic medications may have neurotrophic and neuroprotective effects, making documentation of treatment history essential.Summary Patients' age, sex, age at onset of disease, course of illness and treatment status may affect the detection of regional brain volume changes in people with mood disorders.