PRMT1 is critical to FEN1 expression and drug resistance in lung cancer cells
PRMT1 is critical to FEN1 expression and drug resistance in lung cancer cells
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PRMT1 对于肺癌细胞中 FEN1 的表达和耐药性至关重要。
DOI：
10.1016/j.dnarep.2020.102953
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发表时间：
2020-11-01
期刊：
影响因子：
3.8
通讯作者：
Guo, Zhigang
中科院分区：
文献类型：
--
作者：
He, Lingfeng;Hu, Zhigang;Guo, Zhigang
PRMT1的上调对肺癌细胞的生长和癌变进展至关重要。在我们的研究中，我们发现PRMT1对肺癌细胞的DNA修复能力和耐药性很重要。为了证明PRMT1的功能，我们鉴定了Flap内切酶1 （FEN1）作为PRMT1翻译后修饰的下游靶蛋白。FEN1是碱基切除修复通路的主要组成部分，在DNA复制和DNA损伤修复中发挥重要作用。然而，肺癌细胞中FEN1上调的具体机制尚不清楚。在我们的研究中，我们发现PRMT1是维持FEN1高表达水平的关键因子，而FEN1对肺癌细胞的DNA修复能力和化疗耐药至关重要。
The up-regulation of PRMT1 is critical to the cell growth and cancer progression of lung cancer cells. In our research, we found that PRMT1 is important to the DNA repair ability and drug resistance of lung cancer cells. To demonstrate the functions of PRMT1, we identified Flap endonuclease 1 (FEN1) as a post-translationally modified downstream target protein of PRMT1. As a major component of Base Excision Repair pathway, FEN1 plays an important role in DNA replication and DNA damage repair. However, the detailed mechanism of FEN1 up-regulation in lung cancer cells remains unclear. In our study, we identified PRMT1 as a key factor that maintains the high expression levels of FEN1, which is critical to the DNA repair ability and the chemotherapeutic drug resistance of lung cancer cells.