The planarian Schmidtea mediterranea is a new model to study host-pathogen interactions during fungal infections
The planarian Schmidtea mediterranea is a new model to study host-pathogen interactions during fungal infections
复制标题
DOI：
10.1016/j.dci.2018.12.005
复制
发表时间：
2019-04-01
影响因子：
2.9
通讯作者：
Oviedo, Nestor J.
中科院分区：
文献类型：
--
作者：
Maciel, Eli Isael;Jiang, Cen;Oviedo, Nestor J.
白色念珠菌是人类最常见的真菌病原体之一。目前，现有的动物模型对白色念珠菌感染的评价存在局限性，特别是在了解真菌病原体的特定感染阶段对宿主的影响方面。我们发现白色念珠菌感染、生长和入侵扁平线虫的组织，并通过激活宿主固有免疫系统的组成部分来清除和修复宿主组织来应对感染。我们研究了白色念珠菌感染的不同阶段，并证明了后生动物在进化上可能保守的一个过程，即浮游动物干细胞在真菌感染时增加分裂。我们的结果暗示MORN2和TAK1/p38信号通路可能是宿主对真菌感染的先天免疫反应的中介。我们建议使用平板动物作为一个模型系统来研究真菌感染过程中宿主与病原体的相互作用。
Candida albicans is one of the most common fungal pathogens of humans. Currently, there are limitations in the evaluation of C. albicans infection in existing animal models, especially in terms of understanding the influence of specific infectious stages of the fungal pathogen on the host. We show that C. albicans infects, grows and invades tissues in the planarian flatworm Schmidtea mediterranea, and that the planarian responds to infection by activating components of the host innate immune system to clear and repair host tissues. We study different stages of C. albicans infection and demonstrate that planarian stem cells increase division in response to fungal infection, a process that is likely evolutionarily conserved in metazoans. Our results implicate MORN2 and TAK1/p38 signaling pathways as possible mediators of the host innate immune response to fungal infection. We propose the use of planarians as a model system to investigate host-pathogen interactions during fungal infections.