MicroRNA-31 expression in colorectal serrated pathway progression
MicroRNA-31 expression in colorectal serrated pathway progression
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DOI：
10.3748/wjg.v20.i34.12346
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发表时间：
2014-09-14
影响因子：
4.3
通讯作者：
Shinomura, Yasuhisa
中科院分区：
文献类型：
--
作者：
Aoki, Hironori;Nosho, Katsuhiko;Shinomura, Yasuhisa
MicroRNA已被越来越多地认为是结直肠癌（CRC）的有用生物标志物。我们最近观察到microRNA-31（miR-31）表达与BRAF突变和CRC预后相关。此外，与增生性息肉（HP）相比，无蒂锯齿状腺瘤中经常检测到高miR-31表达。这些结果表明，miR-31可能有助于锯齿状病变的进展。在后续的结肠镜检查中，我们观察到一位75岁的男性在盲肠有一个7毫米的平坦隆起的病变，并诊断为早期浸润性癌与锯齿状的功能。从代表性区域获得组织标本，以比较癌组分与HP组分中的分子改变。与配对的正常粘膜相比，在癌组分（57倍增加）和HP组分（8倍增加）中观察到更高的miR-31表达，这表明miR-31可能是锯齿状途径进展中的关键分子之一。(C)2014百世登出版集团股份有限公司All rights reserved.
MicroRNAs have been increasingly recognized as useful biomarkers for colorectal cancers (CRC). We have recently observed that microRNA-31 (miR-31) expression is associated with BRAF mutation and prognosis in CRC. Moreover, high miR-31 expression is frequently detected in sessile serrated adenomas compared with hyperplastic polyps (HPs). These results suggest that miR-31 may contribute to the progression of serrated lesions. At a follow-up colonoscopy, we observed the case of a 75-year-old man with a 7-mm flat-elevated lesion in the cecum and diagnosed the lesion as an early invasive carcinoma with serrated features. Tissue specimens were obtained from the representative areas to compare the molecular alterations in the carcinoma component with those in the HP component. Higher miR-31 expression was observed in the carcinoma component (57-fold increase) and the HP component (8-fold increase) compared with the paired normal mucosa, suggesting that miR-31 may be one of the key molecules in serrated pathway progression. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.