Elevated levels of oxidized low density lipoprotein show a positive relationship with the severity of acute coronary syndromes
Elevated levels of oxidized low density lipoprotein show a positive relationship with the severity of acute coronary syndromes
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DOI：
10.1161/01.cir.103.15.1955
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发表时间：
2001-04-17
期刊：
影响因子：
37.8
通讯作者：
Becker, AE
中科院分区：
文献类型：
--
作者：
Ehara, S;Ueda, M;Becker, AE
背景-越来越多的数据表明，急性冠状动脉综合征与影响动脉粥样硬化斑块的炎症近期发作激活有关。增加血液中氧化低密度脂蛋白（ox LDL）的水平可以发挥作用，在这些情况下，方法和结果-氧化低密度脂蛋白水平测定135例急性心肌梗死（AMI; n=45），不稳定型心绞痛（UAP; n=45），稳定型心绞痛（SAP; n=45）和46例对照组使用夹心ELISA方法。此外，从SAP（n=10）和UAP（n=23）患者的不同队列中获得的33个斑块切除术标本进行了ox-LDL的化学研究。AMI组ox-LDL水平显著高于UAP组（P
Background-There is accumulating data that acute coronary syndromes relate to recent onset activation of inflammation affecting atherosclerotic plaques. Increased blood levels of oxidized low density lipoprotein (ox LDL) could play a role in these circumstances.Methods and Results-Ox-LDL levels were measured in 135 patients with acute myocardial infarction (AMI; n=45), unstable angina pectoris (UAP; n=45), and stable angina pectoris (SAP; n=45) and in 46 control subjects using a sandwich ELISA method. In addition, 33 atherectomy specimens obtained from a different cohort of patients with SAP (n=10) and UAP (n=23) were studied immunohistochemically for ox-LDL. In AMI patients, ox-LDL levels were significantly higher than in patients with UAP (P