Human T cell lymphotropic virus types I and II in intravenous drug users in San Francisco: risk factors associated with seropositivity.
Human T cell lymphotropic virus types I and II in intravenous drug users in San Francisco: risk factors associated with seropositivity.
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旧金山静脉吸毒者中人类 T 细胞淋巴细胞病毒 I 型和 II 型：与血清阳性相关的危险因素。
DOI：
10.1093/infdis/164.1.36
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Moss,A
中科院分区：
文献类型：
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作者：
Feigal,E;Murphy,E;Vranizan,K;Bacchetti,P;Chaisson,R;Drummond,JE;Blattner,W;McGrath,M;Greenspan,J;Moss,A
1985年至1987年，在弗朗西斯科的676名静脉吸毒者（IVDUs）中进行了人类T细胞嗜淋巴细胞病毒I型和II型（HTLV I/II）感染的血清学检测：1985年150人，1986年44人，1987年482人。采用Western blot、ELISA和p24放免法检测血清。共有111名参与者在至少两次检测中呈血清阳性。静脉注射海洛因的持续时间与HTLV I/II血清阳性的风险密切相关：与使用海洛因10年相比，21年的优势比为6.1（95%置信区间[CI]，2.2-17.5）。其他独立的风险因素包括黑人或西班牙裔，女性，以及在射击场使用毒品。HTLV I/II型和人类免疫缺陷病毒的合并感染率低于预期的偶然感染率（P<0.02）。纵向标本可在154名参与者。经年龄和种族调整的血清转换率为3.4%（95%CI，1.3-8.9）/人/年。在接受检测的349名同性恋男性中，没有人HTLV I/II血清阳性
Serologic assays for human T cell lymphotropic virus types I and II (HTLV I/II) infection were done in 676 intravenous drug users (IVDUs) in San Francisco between 1985 and 1987: 150 in 1985, 44 in 1986, and 482 in 1987. All sera were tested by Western blot, ELISA, and p24 RIA. A total of 111 participants were seropositive in a minimum of two assays. Duration of intravenous heroin use was strongly associated with the risk of HTLV I/II seropositivity: ⩾21 years odds ratio, 6.1 (95% confidence interval [Cl], 2.2–17.5), compared with ⩽10 years of heroin use. Additional independent risk factors included black or Hispanic race, female sex, and the use of drugs in a shooting gallery. Coinfection of HTLV I/II and human immunodeficiency virus was less frequent than expected by chance (P< .02). Longitudinal specimens were available in 154 participants. The age- and race-adjusted seroconversion rate was 3.4% (95% CI, 1.3–8.9) per person per year. Of the 349 homosexual men tested, none were HTLV I/II-seropositive