Protein structure computing in the genomic era
Protein structure computing in the genomic era
复制标题
DOI：
10.1016/s0923-2508(00)00121-2
复制
发表时间：
2000-03-01
影响因子：
2.6
通讯作者：
Peitsch, MC
中科院分区：
文献类型：
--
作者：
Schwede, T;Diemand, A;Peitsch, MC
在完全测序的基因组中发现的蛋白质的功能分析是生命科学研究的下一个主要挑战。计算方法在这一活动中起着至关重要的作用，其中，比较蛋白质模型在诱变实验的合理设计中有很大的帮助。在过去的几年里，我们的目标是在这个领域进一步使用三维模型结构。因此，我们开发了一个比较蛋白质建模环境，该环境由Swiss-PdbViewer（序列构建工作台和查看程序），SWISS-MODEL（基于互联网的模型生成服务器）和3DCrunch生成的模型数据库组成。(C) 2000年版《科学与医学》Elsevier SAS。
Functional analysis of the proteins discovered in fully sequenced genomes represents the next major challenge of life science research. Computational methods play a crucial role in this activity and, among them, comparative protein modelling is of great assistance during the rational design of mutagenesis experiments. Our aim over the last several years has been to further the use of 3-D model structures in this field. Therefore, we have developed a comparative protein modelling environment composed of the Swiss-PdbViewer (sequence to structure workbench and viewing program), SWISS-MODEL (internet-based server for model generation) and a database of a model generated with 3DCrunch. (C) 2000 Editions scientifiques et medicales Elsevier SAS.