THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview.
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview.
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DOI：
10.1111/bph.13882
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发表时间：
2017-12
影响因子：
7.3
通讯作者：
CGTP Collaborators
中科院分区：
文献类型：
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作者：
Alexander SP;Kelly E;Marrion NV;Peters JA;Faccenda E;Harding SD;Pawson AJ;Sharman JL;Southan C;Buneman OP;Cidlowski JA;Christopoulos A;Davenport AP;Fabbro D;Spedding M;Striessnig J;Davies JA;CGTP Collaborators
《药理学简明指南2017/18》是该系列两年出版一次的出版物中的第三本。该版本提供了近1800个人类药物靶点的关键特性的简明概述，重点是选择性药理学（如有），以及药物靶点及其配体的开放获取知识库（www.guidetopharmacology.org）的链接，该知识库提供了靶点和配体特性的更详细视图。虽然《简明指南》约有400页，但与网站上的信息和链接相比，所提供的材料大大减少。它提供了一个永久的，可引用的，时间点记录，将在数据库更新中幸存下来。本节的全部内容可在http://onlinelibrary.wiley.com/doi/10.1111/bph.13882/full上找到。除了这一概述之外，其中确定的“其他蛋白质靶标”不属于后续分类，还有八个重点领域：G蛋白偶联受体，配体门控离子通道，电压门控离子通道，其他离子通道，核激素受体，催化受体，酶和转运体。这些都提出了命名指导和总结信息的最佳可用药理学工具，以及关键的参考文献和建议，以进一步阅读。《简明指南》的景观格式旨在促进从当代材料到2017年中期的相关目标的比较，并取代2015/16和2013/14《简明指南》和以前的《受体和通道指南》中提供的数据。它与基础和临床药理学联盟命名委员会（NC - IUPHAR）密切合作，因此，在适当的情况下，为人类药物靶标提供官方的IUPHAR分类和命名。
The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13882/full. In addition to this overview, in which are identified ‘Other protein targets’ which fall outside of the subsequent categorisation, there are eight areas of focus: G protein‐coupled receptors, ligand‐gated ion channels, voltage‐gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2017, and supersedes data presented in the 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature Committee of the Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.